2005 Fiscal Year Final Research Report Summary
Developmental study of the specific prescription program for the improvement of mental health trouble in human
| Project/Area Number |
14208005
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | National Institute of Fitness and Sports in Kanoya |
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Principal Investigator |
SHIBAYAMA Hidetaro National Institute of Fitness and Sports in Kanoya, President, 学長 (00162644)
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| Co-Investigator(Kenkyū-buntansha) |
KURATA Hiroshi National Institute of Fitness and Sports in Kanoya, Vice President, 副学長 (80056895)
SAITO Kazuto National Institute of Fitness and Sports in Kanoya, Health Service Center, Professor, 保健管理センター, 教授 (50170494)
TAKEKURA Hiroaki National Institute of Health and Nutrition, Sports Performance, Professor, 体育学部, 教授 (00206963)
MIYACHI Motohiko National Institute of Health and Nutrition, Division of Health Promotion and Exercise, Chief, 健康増進研究部, 室長 (60229870)
FUJIMOTO Toshihiko Tohoku University, Center for the Advancement of Higher Education, Lecturer, 高等教育開発推進センター, 講師 (00229048)
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| Project Period (FY) |
2002 – 2005
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| Keywords | mental health / stress / exercise prescription / skeletal muscle / autonomic nervous function / brain / positron emission tomography / 疲労 |
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| Research Abstract |
The overall purpose of this study was to obtain experimental evidences to develop a specific prescription program for the people who have a trouble in mental health. We observed the effects of several exercise combined-programs on the brain tissue, cardiovascular systems, autonomic nervous function, and skeletal muscles of human subjects and experimental animals. The main results of the human studies are summarized as follows.
We investigated the effects of exercise on myocardial glucose uptake and whether the pattern of glucose uptake is the same as in skeletal muscle. Glucose uptake was measured using positron emission topography (PET) and 2-[^<18>F] fluoro-2-deoxy-D-glucose. As compared to the resting state, exercise doubled myocardial glucose uptake at the 30% and 55% intensity levels, while at the 75% intensity level glucose uptake was reduced significantly compared to the lower exercise intensities. At rest and during low-intensity exercise, myocardial glucose uptake was inversely
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associated with circulating levels of free fatty acids. However, during higher exercise intensities when plasma lactate concentrations increased significantly, this association disappeared. This finding suggests that the increased myocardial energy that is needed during high-intensity exercise is supplied by substrates other than glucose.
Reductions in the compliance of central arteries exert a number of adverse effects on systemic cardiovascular function and diseases. Using the cross-sectional study design, we determined the relation between chronic resistance training and carotid arterial compliance. (1)resistance exercise training is associated with the smaller central arterial compliance in health middle-aged men ; (2)age-related reductions in arterial compliance was greater in resistance-trained men than in sedentary men ; (3)the lower arterial compliance in the resistance-trained men is associated with left ventricular hypertrophy. In marked contrast to the beneficial effect of regular aerobic exercise, the present findings are not consistent with the idea that resistance exercise training exerts beneficial influences on arterial wall buffering functions. Less
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[Journal Article] Fluctuations in carotid arterial distensibility during the menstrual cycle do not influence cardiovagal baroreflex sensitivity.2006
Author(s)
Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T, Onodera, S., Mesaki, N.
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Journal Title
Acta Physiol (Oxf). 186
Pages: 103-110
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Variations in carotid arterial compliance during the menstrual cycle.2006
Author(s)
Hayashi, K., Miyachi, M., Seno, N., Takahashi, K., Yamazaki, K., Sugawara, J., Yokoi, T, Onodera, S., Mesaki, N.
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Journal Title
Exp.Physiol. (Epub ahead of print)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] High intensity exercise decreases global brain glucose uptake in humans.2005
Author(s)
Kemppainen, J., Aalto, S., Fujimoto, T., Kalliokoski KK., Langsjo J., Oikonen V., Rinne J., Nuutila P., Knuuti J.
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Journal Title
J.Physiol.(Lond.) 568
Pages: 323-332
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Habitual exercise induced resistance to oxidative stress.2005
Author(s)
Nakatani, K., Komatsu, M., Kato, Y., Yamanaka, T., Takekura, H, Wagatsuma, A., Aoyama, K., Xu, B., Hirano, T., Kasai, H., Ando, S., Takeuchi, T.
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Journal Title
Free Radical Res. 39
Pages: 905-911
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man.2005
Author(s)
Ueno, L.M., Miyachi, M., Matsui, T., Takahashi, K., Yamazaki, K., Hayashi, K., Onodera, S., Moritani, T.
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Journal Title
Braz.J.Med.Biol.Res. 38
Pages: 629-637
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of DHP-receptor arrays in skeletal muscle.2004
Author(s)
Takekura, H., Paoini, C., Franzini-Armstrong, C., Kugler, G., Grabner, M., Flucher, B.E.
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Journal Title
Mol.Biol.Cell. 15
Pages: 5408-5419
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Changes in localization and orientation of triads following selective elimination of cytoskeletal protein in rat skinned muscle fiber.2004
Author(s)
McGrath, K., Nishizawa, T., Yamashita, S., Tamaki, H., Saito, K., Takekura, H.
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Journal Title
Ann.Fitness Sports Sci. 32
Pages: 1-9
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] FDG-PET imaging of lower extremity muscular activity during level walking.2003
Author(s)
Oi, N., Iwaya, T., Itoh, M., Yamaguchi, K., Tobimatsu, Y., Fujimoto, T.
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Journal Title
J.Orthop.Sci. 8
Pages: 55-61
Description
「研究成果報告書概要(欧文)」より
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