Molecular mechanisms for competitive synaptic wiring in cerebellar Purlfinje cells

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 14208091
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hokkaido University
• Principal Investigator: WATANABE Masahiko Hokkaido Univ., Graduated School of Medicine, Prof., 大学院・医学研究科, 教授 (70210945)
• Co-Investigator(Kenkyū-buntansha): FUKUYA Masahiro Hokkaido Univ., Graduated School of Medicine, Inst., 大学院・医学研究科, 助手 (10360900) ; KANO Masanobu Kanazawa Univ., Graduated School of Medicine, Prof., 大学院・医学研究科, 教授 (40185963)
• Project Period (FY): 2002 – 2004
• Keywords: cerebellum / Purkinie cell / climbing fiber / parallel fiber / synapse formation / knockout mouse / calcium channel / glutamate receptor

Research Abstract

Innervation of cerebellar Purkinje cells (PCs) by parallel fibers (PFs) and climbing fibers (CFs) is one of the best model system for synaptic circuit development and maturation. Through our previous analysis on PF synapse-specific molecule GluRd2, we have shown that this molecule strengthens synaptogenesis by PFs. Without GluRd2, PF-PCPC synapses are markedly reduced in number, and many PC spines on distal dendrites became free of synaptic contact (Kurihara et al.,1997, J.Neurosci.17:9613-9623). In this research project, we aimed to clarify what happens for CF in nervation under weakened PF synaptogenesis. By employing anterograde tracer labeling and immunolabeling, distal extension of CF in nervation was shown to occur in GluRd2 knockout mice and innervated free spines on distal dendrites of the PC. The distal extension further occurred against distal dendrites on adjacent PCs, resulting in multiple CF in nervation (Hahimoto et al.,2001;J.Neurosci.21:9701-9712 ; Ichikawa et al.,2002, J.Neurosci.22:8487-8503). These results indicate that synaptogenesis on PC dendrites stands on active competition between PF and CF, in which GluRd2 strengthens PF innervation to distal dendrites. Furthermore, we further revealed that P/Q-type calcium channel alpha-1A, which is activated by CF and induces calcium influx to PC dendrites, is the molecular mechanism that strengthens in nervation by a single major CF at proximal dendrites and expels other lesser CFs and PFs from the dendrites (Miyazaki et al.,2004, J.Neurosci.24:1734-1743).

Research Products

• [Journal Article] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on developing cerebellar Purkinje cells (2004)
  • Author(s): Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • Journal Title: J.Neurosci. 24 Pages: 1734-1743
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • Author(s): Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe.M., Fukaya, M., Ide, C.
  • Journal Title: Genes Cells 9 Pages: 1-14
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. (2004)
  • Author(s): Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., Hirabayashi, Y.
  • Journal Title: J.Biol.Chem. 279 Pages: 3573-3577
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • Author(s): Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 552-569
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Two distinct classes of muscarinic action on hippoccampal inhibitory synapses : M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling. (2004)
  • Author(s): Fukudome, Y., Ohno-Shosaku, T., Matsui, M., Omori, Y., Fukaya, M., Taketo, M., Watanabe, M., Manabe, M., Kano, M.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 2682-2692
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-brain barrier. (2004)
  • Author(s): Nakashima, T., Tomi, M., Katayama, K., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: J.Neurochem. 89 Pages: 1454-1461
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • Author(s): Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 144-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a) in distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • Author(s): Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe, M., Somogy, P.
  • Journal Title: Hippocampus 14 Pages: 193-215
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking (2004)
  • Author(s): Nagy, G.G., Al-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • Journal Title: J.Neurosci. 24 Pages: 5766-5777
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NMDA Receptor GluRe/NR2 subunits are essential for postsynaptic localization and protein stability of GluRz1/NR1 subunit. (2004)
  • Author(s): Abe, M., Fukaya, M., Yagi, T., Mishina, M., Watanabe, M., Sakimura, K.
  • Journal Title: J.Neurosci. 24 Pages: 9292-9304
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • Author(s): Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M., Chun, J., Arai, H.
  • Journal Title: J.Biol.Chem. 279 Pages: 17634-17639
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Changes of high-affinity choline transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • Author(s): Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • Journal Title: Neurosci.Lett. 97 Pages: 97-101
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (2004)
  • Author(s): Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I.
  • Journal Title: Mol Brain Res. 125 Pages: 60-75
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Functional expression of rat ABCG2 and its enhancement by astrocyte-derived soluble factor(s). (2004)
  • Author(s): Hori, S., Ohtsuki, S., Tachikawa, M., Kimura, N., Kondo, T., Watanabe, M., Nakashima, E., Terasaki, T.
  • Journal Title: J.Neurochem. 90 Pages: 526-536
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. (2004)
  • Author(s): Kitamura, H.W., Hamanaka, H., Watanabe, M., Wada, K., Yamazaki, C., Fujita, S.C., Manabe, T., Nukina, N.
  • Journal Title: Neurosci.Lett. 369 Pages: 173-178
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B cclathrin adaptor. (2004)
  • Author(s): Nakatsu, F., Okada, M., Mori, F., Kamazawa, N., Iwasa, H., Zhu, G., Kasagi, Y., Kamiya, H., Harada, A., Nishimura, K., Takeuchi, A., Miyazaki, T., Watanabe, M., Yuasa, S., Manabe, T., Wakabayashi, K., Kaneko, S., Saito, T., Ohno, H.
  • Journal Title: J.Cell Biol. 167 Pages: 293-302
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Upreguration of GluR2 decrease intracellular Ca2+ following ischemia in developing gerbils. (2004)
  • Author(s): Oguro, K., Miyawaki, T., Yokota, H., Kato, K., Kamiya, T., Katayama, Y., Fukaya, M., Watanabe, M., Shimazaki, K.
  • Journal Title: Neurosci.Lett. 364 Pages: 101-105
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Signaling complex formation of phospholipase Cb4 with mGluR1a and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • Author(s): Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 2929-2944
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel action of stargazin as an enhancer of AMPA receptor activity. (2004)
  • Author(s): Yamazaki, M., Ohno-Shosaku, T., Fukaya, M., Kano, M., Watanabe, M., Sakimura, K.
  • Journal Title: Neurosci.Res. 50 Pages: 369-374
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synaptic distribution of the NR1, NR2A, and NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • Author(s): Nagy, G.G., Watanabe.M., Fukaya, M., Todd, R.
  • Journal Title: Eur.J.Neurosci 20 Pages: 3301-3312
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] P/Q-type Ca^<2+> channel α1A regulates synaptic competition on Developing cerebellar Purkinje cells. (2004)
  • Author(s): Miyazaki, M., Hashimoto, K., Shin H.-S., Kano, M., Watanabe, M.
  • Journal Title: J.Neurosci. 24 Pages: 1734-1743
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes. (2004)
  • Author(s): Kinoshita, N., Kimura, K., Matsumoto, N., Watanabe.M., Fukaya, M., Ide, C.
  • Journal Title: Genes Cells. 9 Pages: 1-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] GABAergic basket cells expressing cholecystokinin contain Vesicular glutamate transporter type 3 (VGLUTs) in their synaptic terminals in hippocampus and isocortex of the rat. (2004)
  • Author(s): Somogyi, J., Baude, A., Omori, Y., Shimizu, H., Mestikawy, S.E., Fukaya, M., Ryuichi, S., Watanabe, M., Somogyi, P.
  • Journal Title: Eur.J.Neurosci. 19 Pages: 552-569
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct cellular expressions of creatine synthetic enzyme GAMT And creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis. (2004)
  • Author(s): Tachikawa, M., Fukaya, M., Terasaki, T., Ohtsuki, S., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 144-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunolocalization of metabotropic glutamate receptor 1a (mGluR1a)in distinct classes of interneuron in the CA1 region of the rat hippocampus. (2004)
  • Author(s): Ferraguti, F., Cobden, P., Pollard, M., Cope, D., Shigemoto, R., Watanabe M., Somogy, P.
  • Journal Title: Hippocampus. 14 Pages: 193-215
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen unmasking method. (2004)
  • Author(s): Nagy, G.G., AI-Ayyan, M., Andrew, D., Fukaya, M., Watanabe, M., Todd, A.J.
  • Journal Title: J.Neurosci. 24 Pages: 5766-5777
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NMDA Receptor GluRe/NR2 subunits are essential for postsynaptic localization and protein stability of GluRz1/NR1 subunit. (2004)
  • Author(s): Abe, M., Fukaya, M., Yagi, T., Mishina, M., Watanabe.M., Sakimura, K.
  • Journal Title: J.Neurosci. 24 Pages: 9292-9304
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. (2004)
  • Author(s): Hama, K., Aoki, J., Fukaya, M., Kishi, Y., Sakai, T., Suzuki, R., Ohta, H., Yamori, T., Watanabe, M, Chun, J., Alai, H.
  • Journal Title: J.Biol.Chem. 27 Pages: 17634-17639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes of high-affinity chorine transporter expression during degeneration and regeneration of hypoglossal nerves in mice. (2004)
  • Author(s): Oshima, S., Yamada, K., Shirakawa, T., Watanabe, M.
  • Journal Title: Neurosci.Lett. 97 Pages: 97-101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Signaling complex formation of phospholipase Cb4 with mGluR1 a and IP3R1 at the perisynapse and endoplasmic reticulum in the mouse brain. (2004)
  • Author(s): Nakamura, M., Sato, K., Fukaya, M., Araishi, K., Aiba, A., Kano, M., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 2029-2944
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synaptic distribution of the NR1, NR2A, NR2B subunits of the NMDA receptor in the rat lumbar spinal cord revealed with an antigen unmasking technique. (2004)
  • Author(s): Nagy, G.G., Watanabe, M., Fukaya, M., Todd, R.
  • Journal Title: Eur.J.Neurosci. 20 Pages: 3301-3312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. (2003)
  • Author(s): Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
  • Journal Title: J Neurosci 23 Pages: 550-560
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. (2003)
  • Author(s): Kakizawa S, Yamada K, Watanabe M, Kano M.
  • Journal Title: Eur J Neurosci 17 Pages: 545-554
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • Author(s): Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA 100 Pages: 4855-4860
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-a spartate receptor in the parasympathetic preganglionic neurons in the rat spinal cord. (2003)
  • Author(s): Shibata, T.
  • Journal Title: Dev.Brain Res. 140 Pages: 263-268
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurones in the rat hippocampus. (2003)
  • Author(s): Somogyi, P.
  • Journal Title: Eur.J.Neurosci. 17 Pages: 2503-2520
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Developmental switching of vesicular glutamate transporters at parallel fiber-Purkinjecell synapses. (2003)
  • Author(s): Miyazaki, T.
  • Journal Title: Eur.J.Neurosci. 17 Pages: 2563-2572
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• [Journal Article] Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb. (2003)
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• [Journal Article] Role of thalamic phospholipase Cβ4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. (2003)
  • Author(s): Miyata, M.
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• [Journal Article] Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. (2003)
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  • Journal Title: Dev.Biol. 263 Pages: 216-230
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• [Journal Article] Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. (2003)
  • Author(s): Takahashi, Y.
  • Journal Title: Neurol. 61 Pages: 891-896
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• [Journal Article] Novel neuroglial and glioglial relationships mediated by L-serine metabolism. (2003)
  • Author(s): Furuya, S., Watanabe, M.
  • Journal Title: Arch.Histol.Cytol. 66 Pages: 109-121
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• [Journal Article] Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia, and endoneurial fibroblasts along sciatic nerves and its upregulation after crush injury. (2003)
  • Author(s): Yamashita, N.
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• [Journal Article] Neutral amino acid transporter ASCI1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. (2003)
  • Author(s): Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M
  • Journal Title: J Neurosci. 23 Pages: 550-560
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. (2003)
  • Author(s): Kakizawa S, Yamada K, Watanabe M, Kano M
  • Journal Title: Eur J Neurosci. 17 Pages: 545-554
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. (2003)
  • Author(s): Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M
  • Journal Title: Proc Natl Acad Sci USA. 100 Pages: 4855-4860
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-D-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinalcord. (2003)
  • Author(s): Shibata, T.
  • Journal Title: Dev.Brain Res. 140 Pages: 263-268
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High level of mGluR7 in the presynaptic active zones of select popurations of GABAergic terminals innervating interneurones in the rat hippocampus. (2003)
  • Author(s): Somogyi, P.
  • Journal Title: Eur.J.Neurosci. 17 Pages: 2503-2520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of thalamic phospholipase C□□ mediated by metabotropic glutamate receptor type 1 in inflammatory pain. (2003)
  • Author(s): Miyata, M.
  • Journal Title: J.Neurosci. 23 Pages: 8098-8108
  • Description: 「研究成果報告書概要(欧文)」より
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• [Journal Article] Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluRδ2. (2002)
  • Author(s): Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y., Watanabe, M.
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  • Author(s): Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T
  • Journal Title: J Cereb Blood Flow Metab 22 Pages: 1327-1335
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  • Author(s): Yamada, K., Watanabe, M.
  • Journal Title: Anat.Sci.Int. 77 Pages: 94-108
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Delphilin : A novel PDZ-and Formin homology (FH)-domain containing protein, which interacts with glutamate receptor □2 subunit. (2002)
  • Author(s): Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S
  • Journal Title: J Neurosci 22 Pages: 803-814
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Early onset of NMDA receptor GluR□1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. (2002)
  • Author(s): Oshima S, Fukaya M, Nagashima M, Shirakawa T, Oguchi H, Watanabe M
  • Journal Title: Neurosci Res 43 Pages: 239-250
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Requirement for hippocampal CA3 NMDA receptors in associative memory recall. (2002)
  • Author(s): Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Jhonston D, Wilson MA, Tonegawa S
  • Journal Title: Science. 297 Pages: 211-218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluR□2. (2002)
  • Author(s): Ichikawa, R., Miyazaki, T., Kano, M., Hashikawa, T., Tatsumi, H., Sakimura, K., Mishina, M., Inoue, Y., Watanabe, M.
  • Journal Title: J Neurosci. 22 Pages: 8487-8503
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Group I mGluR signaling via G□q/G□11 secures the induction of long-term potentiation in the hippocampal area CA1. (2002)
  • Author(s): Miura M, Watanabe M, Offermanns S, Simon MI, Kano M
  • Journal Title: J Neurosci. 22 Pages: 8379-8390
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. (2002)
  • Author(s): Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T
  • Journal Title: J Cereb Blood Flow Metab. 22 Pages: 1327-1335
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout. (2002)
  • Author(s): Kinoshita M, Kojima S, Sato K, Watanabe M, Urano A, Ito E
  • Journal Title: Eur J Neurosci. 16 Pages: 868-876
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The delta2 "glutamate receptor is not activated by glutamate-like ligand.
  • Author(s): Hirai, H., Miyazaki, T., Mishina, M., Watanabe.M., Yuzaki, M.
  • Journal Title: EMBO report. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evidence for creatine biosynthesis in Muller glial cells.
  • Author(s): Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: J.Neurochem (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early postnatal motoneurons.
  • Author(s): Fukaya, M., Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum.
  • Author(s): Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J.Neurosci. (印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The delta2 "glutamate receptor is not activated by glutamate-likeligand.
  • Author(s): Hirai, H., Miyazaki, T., Mishina, M., Watanabe, M., Yuzaki, M.
  • Journal Title: EMBO report. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for creatine biosynthesis in Muller glial cells.
  • Author(s): Nakashima, T, Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K.
  • Journal Title: J.Neurochem. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] NR2-to-NR3B subunit conversion of NMDA receptor in early Postnatal motoneurons.
  • Author(s): Fukaya, M., Hayashi, Y., Watanabe, M.
  • Journal Title: Eur.J.Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Control of synaptic connection by glutamate receptor d2 in the mature cerebellum.
  • Author(s): Takeuchi, T., Miyazaki, T., Watanabe, M., Mori, H., Sakimura, K., Mishina, M.
  • Journal Title: J.Neurosci. (in press)
  • Description: 「研究成果報告書概要(欧文)」より