• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Studies on mechanisms for specialization of neocortical areas

Research Project

Project/Area Number 14209018
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionNational Institute for Basic Biology (2004-2005)
Okazaki National Research Institutes (2002-2003)

Principal Investigator

YAMAMORI Tetsuo  National Institute for Basic Biology, Division of Brain Biology, Professor, 脳生物学研究部門, 教授 (80260206)

Co-Investigator(Kenkyū-buntansha) WATAKABE Akiya  National Institute for Basic Biology, Division of Brain Biology, Research Associates, 脳生物学研究部門, 助手 (40290910)
KOMINE Yuriko  National Institute for Basic Biology, Division of Brain Biology, Research Associates, 脳生物学研究部門, 助手 (90280586)
Project Period (FY) 2002 – 2005
Keywordsmotor learning / c-Fos / occ1 / neocortical areas / visual cortex development
Research Abstract

1)We have analyzed the genes that are specifically expressed in neocortical areas. We found that Rbp (retinol binding protein) is specifically expressed in primate association areas. We previously reported that occ1 (occipital 1) is specifically expressed in the primary visual cortex of primates. In this term, we found that occ1 is expressed both excitatory and inhibitory neurons in the primate neocortex. However, the expressions of activity-dependent and area- specific occ1 are only observed in primate neocortices. This suggests that these characteristic features of occ1 expression specifically appeared during the course of primate evolution.
2)We have searched for area-specific genes in primates using RLCS (restriction landmark cDNA scanning) and found a set of genes that are specifically expressed in neocortical areas in primates. We are currently analyzing these genes.
3)We found that the antisense RNA of zfh-5, a novel transcriptional factor, is expressed in a complemental manner in several brain regions. We are currently studying the significance of this antisense RNA expression.
4)In collaboration with professor Yoshio Sakurai, Kyoto University, we improved an audio-visual discrimination system in rats which was originally made by professor Sakurai. In the new system, different modalities (light and sound) are given from the same position to rats which should choose a particular combination of two modalities (the correct stimuli) to get a pellet of food. Using this system, we found that 7-12 Hz oscillation in the frontal cortex increased when rats were shifted from the awake to sleep state. We are currently studying what types of cells in the brain may be involved in this phenomenon.
5)We developed a wheel running apparatus in which rats are asked to adjust a pattern of pegs to drink water in front. We are currently working what types of cells are involved to adjust for the running pattern change of the rat using c-Fos mapping techniques.

  • Research Products

    (25 results)

All 2006 2005 2004 2003 2002

All Journal Article (25 results)

  • [Journal Article] Novel transcription factor zfh-5 is negatively regulated by its own anitisense RNA in mouse brain.2006

    • Author(s)
      Komine Y.
    • Journal Title

      Mol Cell Neurosci. 31

      Pages: 273-283

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gene expression profiling of primate neocortex : molecular neuroanatomy of cortical areas2006

    • Author(s)
      Watakabe, A.
    • Journal Title

      Genes Brain Behav 5 Suppl 1

      Pages: 38-43

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain.2006

    • Author(s)
      Komine Y.
    • Journal Title

      Mol Cell Neurosci. 31

      Pages: 273-283

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activity-dependent expression of occ1 in excitatory neurons is a characteristic of the primate visual cortex.2005

    • Author(s)
      Takahata T.
    • Journal Title

      Cerbral Cortex. Epub ahead of print

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 7-12 Hz cortical oscillations : behavioral contex and dynamics of prefrontal neuronal ensembles.2005

    • Author(s)
      Sakata S.
    • Journal Title

      Neuroscience 134

      Pages: 1099-1111

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Local design principles of mammalian cortical networks.2005

    • Author(s)
      Sakata S.
    • Journal Title

      Neurosci.Res. 51

      Pages: 309-315

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Retinol-binding Protein gene is Highly Expressed in Higher-order Association Areas of Primate Neocortex.2005

    • Author(s)
      Komatsu Y.
    • Journal Title

      Cereb Cortex. 15

      Pages: 96-108

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Activity-dependent expression of occ1 in excitatory neurons is a characteistic feature of the primate visual cortex.2005

    • Author(s)
      Takahata T.
    • Journal Title

      Cerbral Cortex. (Epub ahead of print)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Retinol-binding Protein gene is Highly Expressed in Higher-order Association Areas of the Primate Neocortex.2005

    • Author(s)
      Komatsu Y.
    • Journal Title

      Cereb Cortex. 15

      Pages: 96-108

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Behavioral studies of auditory-visual spatial recognition and integration in rats.2004

    • Author(s)
      Sakata S.
    • Journal Title

      Exp Brain Res 159

      Pages: 409-417

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A voltage-gated potassium channel,Kv3.1b,is expressed by a subpopulation of large pyramidal neurons in layer 5 of the macaque monkey cortex.2004

    • Author(s)
      Ichinohe N.
    • Journal Title

      Neuroscience 129

      Pages: 179-185

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Activation of syntaxin 1C,an alternative splice variant of HPC-1/syntaxin 1A,by phorbol 12-myristate 13-acetate(PMA)suppresses glucose transport into astroglioma cells via the glucose transporter-1(GLUT-1).2004

    • Author(s)
      Nakayama T.
    • Journal Title

      J Biol Chem 279

      Pages: 23728-23739, 114-116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A voltage-gated potassium channel, Kv3.1b, is expressed by a subpopulation of large pyramidal neurons in layer 5 of the macaque monkey cortex.2004

    • Author(s)
      Ichinohe N.
    • Journal Title

      Neuroscience 129

      Pages: 179-185

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).2004

    • Author(s)
      Nakayama T.
    • Journal Title

      J Biol Chem 279

      Pages: 23728-23739, 114-116

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] occ1 mRNA reveals a characteristic feature in the hippocampal CA2 field of adult macaques.2003

    • Author(s)
      Tochitani, S.
    • Journal Title

      Neuroscience Lett. 346

      Pages: 105-108

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ciliary neurotrophic factor inhibits differentiation of photoreceptor-like cells in rat pineal glands in vitro.2003

    • Author(s)
      Hata, K.
    • Journal Title

      Dev.Brain Res. 143

      Pages: 179-187

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification of the carboxyl-terminal membrane-anchoring gegion of HPC-1/Syntaxin 1A with the substituted-cysteine-accessibility method and monoclonal antibodies.2003

    • Author(s)
      Suga, K.
    • Journal Title

      J.Biochem. 133

      Pages: 325-334

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of syntaxin 1C,an alternive splice variant of HPC_1A,is activaed by phorbol-ester stimulation in astrglioma.2003

    • Author(s)
      Nakayana, T.
    • Journal Title

      FEBS Lett. 536

      Pages: 209-214

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of occ1 mRNA in the visual cortex during postnatal development in macaques.2003

    • Author(s)
      Tochitani, S.
    • Journal Title

      Neurosc.Lett. 337

      Pages: 114-116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ciliary neurotrophic factor inhibits differentiation of photorecptor-like cells in rat pineal glands in vitro.2003

    • Author(s)
      Hata, K.
    • Journal Title

      Dev.Brain Res. 143

      Pages: 179-187

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of syntaxin 1C, an alternive splice variant of HPC-1/syntaxin 1A, is activaed by phorbol-ester stimulaton in astrglioma.2003

    • Author(s)
      Nakayana, T.
    • Journal Title

      FEBS Lett. 536

      Pages: 209-214

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] CNTF is specifically expressed in the developing rat pineal gland and eyes.2002

    • Author(s)
      Hata, K.
    • Journal Title

      NeuroReport 13

      Pages: 735-739

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Task-dependent and cell-type-specific Fos enhancement in rat sensory cortices during audio-visual discrimination.2002

    • Author(s)
      Sakata, S.
    • Journal Title

      Eur.J.Neurosci. 15

      Pages: 735-743

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Variations in ling-term and middle-wavelength-sensitive opsin loci in crab-eating monkeys.2002

    • Author(s)
      Onishi, A.
    • Journal Title

      Vision Res. 42

      Pages: 281-292

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synaptic LTD in vivo recorded on the rat cerebellar cortex.2002

    • Author(s)
      Vigot, R.
    • Journal Title

      Arch.Ital.Biol. 140

      Pages: 1-12

    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi