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2004 Fiscal Year Final Research Report Summary

A genetic-ecological study of the risk foctors for lifestyle-related diseases in Oceanian populations

Research Project

Project/Area Number 14255008
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 人類学(含生理人類学)
Research InstitutionThe University of Tokyo

Principal Investigator

OHTSUKA Ryutaro  The University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (60010071)

Co-Investigator(Kenkyū-buntansha) ISHIDA Takahumi  The University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・理学系研究科, 助教授 (20184533)
OHASHI Jun  The University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (80301141)
YAMAUCHI Taro  The University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (70345049)
NATSUHARA Kazumi  The University of Tokyo, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (00345050)
NAKAZAWA Minato  Gunma University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40251227)
Project Period (FY) 2002 – 2004
Keywordschronic degenerative disease / lifestyle-related disease / genetic ecology / diabetes / obesity / lifestyle / modernization / thrifty genotype hypothesis
Research Abstract

We examined the relationships between genetic characteristics and environmental factors associated with the risk factors for lifestyle-related diseases, such as obesity and diabetes, for six Austronesian populations on Oceanian islands. The target populations consisted of one from Tonga, two from Indonesia, and three from the Solomon Islands.
Based on the mean body mass index(BMI), the Tongan population was judged ‘obese' and their waist-to-hip ratio tended to increase with age. Significant correlations were found between diabetic morbidity and indices of obesity, such as BMI and waist circumference. The results also suggested that abdomen fatness was a significant risk factor for abnormal glucose tolerance. By contrast, the mean BMI of the Indonesian populations was considerably lower than that of their Tongan counterparts, and they were categorized as ‘normal'. In the Indonesian populations, the fasting blood glucose was significantly correlated with blood pressure, while there was no significant relationship between diabetes and obesity indices. The populations of the three Solomon Islands consisted of two Melanesian groups that differed in their degree of modernization, and one group of Micronesian migrants from the Gilbert Islands (Kiribati). Their average BMI was higher than that of Indonesians, but lower than that of Tongans. Based on the BMI, men were categorized as ‘normal', and women as ‘overweight'. The urine dipstick test revealed that the Melanesian group with the low degree of modernization maintained a traditional diet (e.g., staple tubers, local greens, and fish). The results appear to reflect synergy between genetic characteristics and environmental factors, especially dietary patterns.

  • Research Products

    (35 results)

All 2005 2004 2003 2002

All Journal Article (27 results) Book (8 results)

  • [Journal Article] Child nutritional status and mortality in a Sundanese village, Indonesia.2005

    • Author(s)
      Sekiyama M, Ohtsuka R
    • Journal Title

      Journal of Biosocial Science (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Rural-urban migration and changing physical activity among Papua New Guinea Highlanders from the perspective of energy expenditure and time use.2005

    • Author(s)
      Yamauchi T, Umezaki M
    • Journal Title

      Environmental Sciences (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impacts of selective logging on New Georgia Island, Solomon Islands evaluated using very-high-resolution-satellite (IKONOS) data.2004

    • Author(s)
      Furusawa T, Pahari K, Umezaki M, Ohtsuka R
    • Journal Title

      Environmental Conservation 31

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular polymorphism of ABO blood group gene in Austronesian and Non-Austronesian populations in Oceania.2004

    • Author(s)
      Ohashi J, Naka I, Ohtsuka R, Inaoka T, Ataka Y et al.
    • Journal Title

      Tissue Antigens 63

      Pages: 355-361

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Adaptive strategies of Highlands-origin migrant settlers in Port Moresby, Papua New Guinea.2003

    • Author(s)
      Umezaki M, Ohtsuka R
    • Journal Title

      Human Ecology 31

      Pages: 3-25

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Systematic search for single nucleotide polymorphisms (SNPs) in the FOXC2 gene : The Absence of evidence for the association of three frequent SNPs and four common haplotypes with Japanese type 2 diabetes.2003

    • Author(s)
      Osawa H, Onuma H, Murakami A, Ohashi J et al.
    • Journal Title

      Diabetes 52

      Pages: 562-567

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Distribution of a 27-bp deletion in the band 3 gene in South pacific islanders.2003

    • Author(s)
      Kimura M, Nakazawa M, Ohtsuka R, Ishida T et al.
    • Journal Title

      Journal of Human Genetics 48

      Pages: 642-645

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Leber's hereditary optic neuropathy with 14484 mutation in Central Java, Indonesia.2003

    • Author(s)
      Nisioka T, Tasaki M, Soemantri Ag, Ishida T et al.
    • Journal Title

      Journal of Human Genetics 48

      Pages: 385-389

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The SDF1-G801A polymorphism is not associated with SDF1 gene expression in Epstein-Barr virus-transmitted lymphoblastoid cells.2003

    • Author(s)
      Kimura M, Nishioka T, Ishida T
    • Journal Title

      Genes and Immunity 4

      Pages: 356-361

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The absence of evidence for major effects of the frequent SNP +299 G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes.2003

    • Author(s)
      Ochi M, Osawa H, Onuma H, Ohashi J et al.
    • Journal Title

      Diabetes Research and Clinical Practice 61

      Pages: 191-198

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] HLA-DRB1 polymorphism of Balopa islanders in Papua New Guinea.2003

    • Author(s)
      Tarasenko O, Ohashi J, Ohtsuka R, Tokunaga K et al.
    • Journal Title

      Anthropological Science 111

      Pages: 157-164

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Power of association test for detection minor histocompatibility gene causing graft-versus-host disease following bone marrow transplantation.2003

    • Author(s)
      Ohashi J, Maruya E, Tokunaga K, Saji H
    • Journal Title

      Journal of Human Genetics 48

      Pages: 502-507

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The power of genome-wide linkage disequilibrium (LD) testing using microsatellite markers.2003

    • Author(s)
      Ohashi J, Tokunaga K
    • Journal Title

      Journal of Human Genetics 48

      Pages: 487-491

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Variation in malaria endemicity in relation to microenvironmental conditions in the Admiralty Islands, Papua New Guinea.2003

    • Author(s)
      Ataka Y, Ohtsuka R, Ohashi J, Tokunaga K et al.
    • Journal Title

      Asia-Pacific Journal of Public Health 13

      Pages: 85-90

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DNA sequence variation of the human ABO-secretor locus (FUT2) in New Guinean populations : possible early human migration from Africa.2003

    • Author(s)
      Koda, Y., Ishida, T., Tachida, H., Wang, BJ et al.
    • Journal Title

      Human Genetics 113

      Pages: 1013-1016

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Systematic search for single nucleotide polymorphisms(SNPs) in the FOXC2 gene : The Absence of evidence for the association of three frequent SNPs and four common haplotypes with Japanese type 2 diabetes.2003

    • Author(s)
      Osawa H, Onuma H, Murakami A, Ohashi J et al.
    • Journal Title

      Diabetes 52

      Pages: 562-567

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Distribution of a 27-bp deletion in the band 3 gene in South Pacific islanders.2003

    • Author(s)
      Kimura M, Nakazawa M, Ohtsuka R, Ishida T et al.
    • Journal Title

      Journal of Human Genetics 48

      Pages: 642-645

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes.2003

    • Author(s)
      Ochi M, Osawa H, Onuma H, Ohashi J et al.
    • Journal Title

      Diabetes Research and Clinical Practice 61

      Pages: 191-198

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Power of association test for detection minor bistocompatibility gene causing graft-versus-host disease following bone marrow transplantation.2003

    • Author(s)
      Ohashi J, Maruya E, Tokunaga K, Saji H
    • Journal Title

      Journal of Human Genetics 48

      Pages: 502-507

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The power of genome-wide linkage disequilibrium(LD) testing using microsatellite markers.2003

    • Author(s)
      Ohashi J, Tokunaga K
    • Journal Title

      Journal of Human Genetics 48

      Pages: 487-491

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Community health assessment by urine dipstick screening in relation to the variety of lifestyles in the Solomon Islands.2002

    • Author(s)
      Nakazawa M, Yamauchi T, Ohtsuka R et al.
    • Journal Title

      People and Culture in Oceania 18

      Pages: 35-44

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Time allocation to subsistence activities among the Huli in rural and urban Papua New Guinea.2002

    • Author(s)
      Umezaki M, Yamauchi T, Ohtsuka R
    • Journal Title

      Journal of Biosocial Science 34

      Pages: 133-137

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Distinctive distribution of AIM1 polymorphism among major human populations with different skin color.2002

    • Author(s)
      Nakayama K, Fukamachi S, Kimura R, Ishida T et al.
    • Journal Title

      Journal of Human Genetics 47

      Pages: 92-94

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anthropological implication of the SDF1-3'A allele distribution in Southeast Asia and Melanesia.2002

    • Author(s)
      Kimura R, Ohtsuka R, Inaoka T, Ishida T et al.
    • Journal Title

      Journal of Human Genetics 47

      Pages: 117-121

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Changing migration patterns of the Huli in Papua New Guinea Highlands : a genealogical-demographic analysis.2002

    • Author(s)
      Umezaki M, Ohtsuka R
    • Journal Title

      Mountain Research and Development 22

      Pages: 256-262

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The expected power of genome-wide linkage disequilibrium testing using single nucleotide polymorphism markers for detecting a low-frequency disease variant.2002

    • Author(s)
      Ohashi J, Tokunaga T
    • Journal Title

      Annals of Human Genetics 66

      Pages: 297-306

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Systematic search for single nucleotide polymorphisms in the resistin gene : the absence of evidence for association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.2002

    • Author(s)
      Osawa H, Onuma H, Murakami A, Ohashi J et al.
    • Journal Title

      Diabetes 51

      Pages: 863-866

    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Tongan obesity. In : Health Change in the Asia-Pacific Region(R Ohtsuka R, S J Ulijaszek (eds.))2005

    • Author(s)
      Inaoka T
    • Publisher
      Cambridge University Press
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Modernization, nutritional adaptability, and health in Papua New Guinean Highlanders and Solomon Islanders. In : Health Change in the Asia-Pacific Region(R Obtsuka R, S J Ulijaszek (eds.))2005

    • Author(s)
      Yamauchi T
    • Publisher
      Cambridge University Press
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Tongan obesity(R Ohtsuka R, S J Ulijaszek(eds.))2005

    • Author(s)
      Inaoka T
    • Publisher
      Cambridge University Press
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Modernization, nutritional adaptability, and health in Papua New Guinean Highlanders and Solomon Islanders(R Ohtsuka R, S J Ulijaszek(eds.))2005

    • Author(s)
      Yamauchi T
    • Publisher
      Cambridge University Press
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Environmental preservation and community welfare under rural development projects : a comparative ethnoecological study in Asia and Oceania. In : Nature and Human Communities(Sasaki T (ed)), pp. 45-65.2004

    • Author(s)
      Ohtuska R
    • Total Pages
      210
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Environmental preservation and community welfare under rural development projects : a comparative ethnoecological study in Asia and Oceania(Sasaki T (ed))2004

    • Author(s)
      Ohtuska R
    • Total Pages
      45-65
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 講座生態人類学 第5巻:ニューギニア-交錯する伝統と近代2002

    • Author(s)
      大塚柳太郎, 梅崎昌裕, 稲岡 司, 安高雄治ほか
    • Total Pages
      245
    • Publisher
      京都大学学術出版会
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Ecological Anthropology 5 : New Guinea Between Tradition and Modernity(R Ohtsuka(eds.))2002

    • Author(s)
      Ohtuska R, Umezaki M, Inaoka T, Ataka Y et al.
    • Publisher
      Kyoto University Press
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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