Development of a super-parallel MR microscope for construction of a 3D image database of human embryos

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14350039
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied physics, general
• Research Institution: University of Tsukuba
• Principal Investigator: KOSE Katsumi University of Tsukuba, Institute of Applied Physics, Professor, 物理工学系, 教授 (60186690)
• Project Period (FY): 2002 – 2003
• Keywords: MRI / NMR / MR microscope / Human embryo / embryo / 3D image / Super-parallel / super-conducting magnet

Research Abstract

Kyoto University has a large human embryo collection (〜50,000 specimens), which were collected from 1961 to 1974. Because such a collection will never be obtained again, their nondestructive 3Dmeasurements are highly desired. Kyoto and Tsukuba Universities have therefore started a project acquiring 3D MR microscopic images of about 1,200 embryos in two years to create a 3D anatomical database for human embryology. Human embryo specimens were chemically fixed in Bouin's fluid and stored in 10% formalin solution. The embryos were imaged in the formalin to avoid susceptibility effect, with a four-or eight-channel super-parallel MR microscope using a 2.34 T/40 cm superconducting magnet. All of the embryos (about 100 speciments for each stage) were measured using a T_1 weighted 3D SE sequence. The image matrix was 128 x 128 x 256 throughout the whole stages but the voxel size was varied from (40μm)^3 to (150μm)^3. Many anatomical structures were clearly visualized in the 3D images. This result demonstrates usefulness of the anatomical image database in human embryology.

Research Products

• [Journal Article] Development of a Compact MRI System for Trabecalar Bone Volume Fraction Measurements (2004)
  • Author(s): Kose et al.
  • Journal Title: Magnetic Resonance Medicine 52 Pages: 440-444
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of a Compact MRI System for Trabecular Bone Volume Fraction Measurements (2004)
  • Author(s): Katsumi Kose, Yoshimasa Matsuda, Takeaki Kurimoto, Seitarou Hashimoto, Yukako Yamazaki, Tomoyuki Haishi, Shin Utsuzawa, Hiroshi Yoshioka, Shigemasu Okada, Masaaki Aoki, Tsuyoshi Tsuzaki
  • Journal Title: Magn Reson Med 52 Pages: 440-444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Super-parallel MR Microscope (2003)
  • Author(s): Matsuda et al.
  • Journal Title: Magnetic Resonance in Medicine 50・1 Pages: 183-189
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] MR microscopy of the a (2003)
  • Author(s): Yoshioka et al.
  • Journal Title: Magnetic Resonance in Medical Science 2 Pages: 51-55
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Three-dimensional snow images by MR microscopy (2003)
  • Author(s): Ozeki et al.
  • Journal Title: Magnetic Resonance Imaging 21 Pages: 351-354
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Super-parallel MR Microscope (2003)
  • Author(s): Yoshimasa Matsuda, Shin Utsuzawa, Takeaki Kurimoto, Tomoyuki Haishi, Yukako Yamazaki, Katsumi Kose, Izumi Anno, Mitsuhiro Marutani
  • Journal Title: Magn Reson Med 50 Pages: 183-189
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MR microscopy of the articular cartilage with a 1.0T permanent magnet portable MR system : preliminary results (2003)
  • Author(s): Hiroshi Yoshioka, Tomoyuki Haishi, Takaaki Uematsu, Yoshimasa Mstsuda, Yuji Itai, Katsumi Kose
  • Journal Title: Magnetic Resonance in Medical Science 2 Pages: 51-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Three-dimensional snow images by MR microscopy (2003)
  • Author(s): Toshihiro Ozeki, Katsumi Kose, Tomoyuki Haishi, Seitarou Hashimoto, Shun-ichi Nakatsubo, Kouichi Nishimura
  • Journal Title: Magn Reson Imaging 21 Pages: 351-354
  • Description: 「研究成果報告書概要(欧文)」より