2003 Fiscal Year Final Research Report Summary
On novel capsaicinoid-like substances in the fruit of new non-pungent pepper (Capsicum annuum) development of growing method and materials for food industry
| Project/Area Number |
14360021
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
園芸・造園学
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
YAZAWA Susumu KYOTO UNIVERSITY Graduate School of Agriculture, Professor, 農学研究科, 教授 (90026550)
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| Co-Investigator(Kenkyū-buntansha) |
OHIGASHI Hajime KYOTO UNIVERSITY Graduate School of Agriculture, Professor, 農学研究科, 教授 (80026583)
WATANABE Tatsuo Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Associate Professor, 食品栄養学部, 助教授 (10210915)
FUSHIKI Tohru KYOTO UNIVERSITY Graduate School of Agriculture, Professor, 農学研究科, 教授 (20135544)
HASHIZUME Shuichi Lab.of Nutritional and Food Science Res. Int. Morinaga and Co.Ltd, Research Manager, 研究所, 理事(研究職)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Pepper / CH-19 Sweet / Capsinoid / Capsaicin-like substance / Metabolism of fatty acid in human body / Breeding of endogenous component / Increasing of body temperature / Functional compounds |
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| Research Abstract |
In 1979, Yazawa introduced a hot pepper CH-19 Pungent' from Thailand and produced the original non-pungent pepper by selfing and selection of CH-19 Pungent' and named it 'CH-19 Sweet'. Yazawa found that 'CH-19 Sweet' fruit is little pungent, but contains capsaicinoid like substances (CLSs, tentatively named CLS-A, CLS-B). Kobata et al. (1998) found that CLS-A is a vanillyl alcohol and CLS-B is a capsaicin analog. CLS-B was named capsiate. Capsinoid was reported to increase body temperature in mice and human. Capsinoid is non-pungent so. that it may be possible to utilize a considerable amount of capsinoid for food and drug applications. In this research project, we got the following results.
1. Establishment of growing method in a resting paddy field.
2. Harvesting time of fruits highly containing capsinoid and condition of the strage-transportation were decided.
3. Capsinoid biosynthetic pathway (phenylalanine-vanillin-vanillyl alcohol-capsinoid) was decided.
4. Capsinoid may be an alterative to capsaicin for the therapeutic treatment of obesity in humans, and implies the existence of a novel VR subtype distinct from nociceptors such as VR1, or presents a new perspective on the functional of VR1.
5. In leaves of 'CH-19 sweet' and the hybrid (F1, CMS strain x 'CH-19 Sweet'), the physiological functional compounds were found out. F1 young plants were useful for vegetable in summer season in Japan.
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[Publications] Iida, T., Moriyama,.T., Kobata,.K:, Morita, A., Mwayama, N., Hashizume, S., Fushiki, T., Yazawa, S., Watanabe, T, Tominaga M.: "TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate"Neuropharmacology. 44. 958-967 (2003)
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