| Research Abstract |
We have been studied the function of nuclear receptors in terms of gene regulations. In the present study, to reveal the molecular basis of the ligand-induced transactivation of nuclear receptors, nuclear, mplexes associated with nuclear receptors have been biochemically purified. The complexes include co-repressor, co-activator and chromatin remodeling ones. Among them, we have extensively investigated the function of one of chromatin remodeling complexes, WINAC. WINAC appears to associate with VDR to bring it to the target gene promoters through reorganization of surrounding nucleosome arrays. Upon ligand binding, the other classes of co-regulator complexes are recruited to VDR/WINAC in the gene promoters.
We have been studied the function of nuclear receptors in terms of gene regulations. In the present study, to reveal the molecular basis of the ligand-induced transactivation of nuclear receptors, nuclear, mplexes associated with nuclear receptors have been biochemically purified. The complexes include co-repressor, co-activator and chromatin remodeling ones. Among them, we have extensively investigated the function of one of chromatin remodeling complexes, WINAC. WINAC appears to associate with VDR to bring it to the target gene promoters through reorganization of surrounding nucleosome arrays. Upon ligand binding, the other classes of co-regulator complexes are recruited to VDR/WINAC in the gene promoters.
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