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2004 Fiscal Year Final Research Report Summary

New Neurophysiological functions of taurine

Research Project

Project/Area Number 14360071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionThe University of Tokyo

Principal Investigator

HISATSUNE Tatsuhiro  The University of Tokyo, Graduate School of Frontier Sciences, Associate Professor, 大学院・新領域創成科学研究科, 助教授 (10238298)

Project Period (FY) 2002 – 2004
KeywordsTaurine / Amino acid / Development / Mammals / Glycine receptors / GABA receptors / Physiology
Research Abstract

Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in the developing mammalian cerebral cortex ; however few studies have reported its neurobiological functions during development. In this study, by means of whole-cell patch-clamp recordings, we examined the effects of taurine on chloride channel receptors in neocortical neurons from early to late postnatal stages, which cover a critical period in cortical circuit formation. We show here that taurine activates chloride channels in cortical neurons throughout the postnatal stages examined (from postnatal day 2 to day 36). The physiological effects of taurine changed from excitatory to inhibitory due to variations in the intracellular Cl^- concentration during development. An antagonist blocking analysis also demonstrated a developmental shift in the receptor target of taurine, from glycine receptors to GABA_A receptors. Taken together, these results may reflect genetically programmed, bidirectional functions of taurine. At the early developmental stage, taurine acting on glycine receptors would serve to promote cortical circuit formation. As the target for taurine shifts to the GABA_A receptor, taurine would assume an alternative function as a neuroprotector of developing neural circuitry, which tends to be hyperactive during development.

  • Research Products

    (19 results)

All 2005 2004 2003

All Journal Article (12 results) Book (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Layer-specific production of nitric oxide during cortical circuit formation in postnatal mouse brain2005

    • Author(s)
      Imura T, Kanatani S, Fukuda S, Miyamoto Y, Hisatsune T
    • Journal Title

      Cerebral Cortex 15

      Pages: 332-340

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Layer-specific production of nitric oxide during cortical circuit formation in postnatal mouse brain2005

    • Author(s)
      Imura T ; Kanatani S ; Fukuda S ; Miyamoto Y ; Hisatsune T
    • Journal Title

      Cerebral Cortex 15

      Pages: 332-340

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Developmental shift in bidirectional functions of taurine-sensitive chloride channels during cortical circuit formation in postnatal mouse brain2004

    • Author(s)
      Yoshida M, Fukuda S, Tozuka Y, Miyamoto Y, Hisatsune T
    • Journal Title

      Journal of Neurobiology 60

      Pages: 166-175

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Developmental shift in bidirectional functions of taurine-sensitive chloride channels during cortical circuit formation in postnatal mouse brain2004

    • Author(s)
      Yoshida M ; Fukuda S ; Tozuka Y ; Miyamoto Y ; Hisatsune T
    • Journal Title

      Journal of Neurobiology 60

      Pages: 166-175

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Non-renewal of neurons in the cerebral neocortex of adult Macaque monkeys2003

    • Author(s)
      Koketsu D, Mikami A, Miyamoto Y, Hisatsune T
    • Journal Title

      Journal of Neuroscience 23

      Pages: 937-942

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus2003

    • Author(s)
      Fukuda S, Kato F, Tozuka Y, Yamaguchi M, Miyamoto Y, Hisatsune T
    • Journal Title

      Journal of Neuroscience 23

      Pages: 9357-9366

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Decrease in expression of α5β1 integrin during neuronal differentiation of cortical progenitor cells2003

    • Author(s)
      Yoshida N, Hishiyama S, Yamaguchi M, Hashiguchi M, Miyamoto Y, Kaminogawa S, Hisatsune T
    • Journal Title

      Experimantal Cell Research 287

      Pages: 262-271

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] NMDA receptors in cortical development are essential for the generation of coordinated increases in [Ca^<2+>]_i in "Neuronal Domains"2003

    • Author(s)
      Okada H, Miyakawa N, Mori H, Mishina M, Miyamoto Y, Hisatsune T
    • Journal Title

      Cerebral Cortex 13

      Pages: 749-757

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Non-renewal of neurons in the cerebral neocortex of adult Macaque monkeys2003

    • Author(s)
      Koketsu D ; Mikami A ; Miyamoto Y ; Hisatsune T
    • Journal Title

      Journal of Neuroscience 23

      Pages: 937-942

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus2003

    • Author(s)
      Fukuda S ; Kato F ; Tozuka Y ; Yamaguchi M ; Miyamoto Y ; Hisatsune T
    • Journal Title

      Journal of Neuroscience 23

      Pages: 9357-9366

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Decrease in expression of α 5 β 1 integrin during neuronal differentiation of cortical progenitor cells2003

    • Author(s)
      Yoshida N ; Hishiyama S ; Yamaguchi M ; Hashiguchi M ; Miyamoto Y ; Kaminogawa S ; Hisatsune T
    • Journal Title

      Experimantal Cell Research 287

      Pages: 262-271

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] NMDA receptors in cortical development are essential for the generation of coordinated increases in [Ca^<2+>]_i in "Neuronal Domains"2003

    • Author(s)
      Okada H ; Miyakawa N ; Mori H ; Mishina M ; Miyamoto Y ; Hisatsune T
    • Journal Title

      Cerebral Cortex 13

      Pages: 749-757

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 「神経系(脳)における食情報の受容と伝達」 食品の科学(上野川修一, 田野倉優編集)2005

    • Author(s)
      久恒辰博
    • Total Pages
      6
    • Publisher
      東京化学同人
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 脳と体のしくみ絵辞典2004

    • Author(s)
      久恒辰博
    • Total Pages
      80
    • Publisher
      PHP研究所
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 「幸せ脳」を作る50の習慣2004

    • Author(s)
      久恒辰博
    • Total Pages
      223
    • Publisher
      PHP研究所
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] ベストな脳の育て方2004

    • Author(s)
      久恒辰博
    • Total Pages
      192
    • Publisher
      中経出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 「幸せ脳」は自分でつくる2003

    • Author(s)
      久恒辰博
    • Total Pages
      216
    • Publisher
      講談社
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 脳梗塞の予防又は治療剤、及び機能性食品2005

    • Inventor(s)
      久恒辰博, 伊東英恵, 徳武昌一, 片山弘
    • Industrial Property Number
      特許(特願2005-106312)
    • Filing Date
      2005-04-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] ラクナ性脳梗塞の非ヒト霊長類疾患モデル動物2004

    • Inventor(s)
      久恒辰博, 川原信隆, 吉川泰弘
    • Industrial Property Number
      特許(特願2004-253205)
    • Filing Date
      2004-08-31
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2007-12-13  

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