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2003 Fiscal Year Final Research Report Summary

Analysis of Regulatory Mechanism of Hepatic Autophagy and Its Contribution to Nutritional Science

Research Project

Project/Area Number 14360072
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 食品科学・栄養科学
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

KADOWAKI Motoni  NIIGATA UNIVERSITY, Faculty of Agriculture, Professor, 農学部, 教授 (90126029)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Fumiaki  Utsunomiya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10269243)
FUJIMURA Shinobu  NIIGATA UNIVERSITY, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (20282999)
Project Period (FY) 2002 – 2003
KeywordsAutophagy / Liver / Proteolysis / Amino Acid / LC3 / Rice Protein / Signaling
Research Abstract

1.Nutritional Role of Hepatic Autophagy
In order to investigate if food protein affects autophagic proteolysis in the liver in the steady state, casein, soybean protein, rice protein, wheat protein, potato protein and ovalbumin, were compared. Animal protein tended to increase the proteolytic rate compared to vegetable protein, but rice protein exceptionally increased the rate, which suggests some special role.
2.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 門脇 基二: "筋肉におけるバルク蛋白質分解-大いなる例外か-"医学のあゆみ. 200(4). 301-304 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kadowaki, M, Kanazawa, T: "Amino acids as regulators of proteolysis"Journal of Nutrition. 133. 2052S-2056S (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shibata, M.et al.: "Nucleotide sequence of myostatin gene and its developmental expression in skeletal muscles of Japanese Black cattle"Animal Science Journal. 74. 383-390 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 金澤 匠, 門脇 基二: "アミノ酸によるオートファジーの調節-タンパク質分解系を中心に-"栄養評価と治療. 20. 483-486 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 門脇 基二, 金澤 匠: "肝オートファジーのシグナリング機構"生体の科学. 54. 528-533 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanazawa, T.et al.: "Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes"Journal of Biological Chemistry. 279. 8452-8459 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kadowaki M.: "Bulk proteolysis in skeletal muscle."Igaku no ayumi. 2004(4). 301-304 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kadowaki, M., Kanazawa, T.: "Amino acids as regulators of proteolysis."Journal of Nutrition. 133. 2052S-2506S (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibaba, M.et al.: "Nucleotide sequence of myostatin gene and its developmental expression in skeletal muscle of Japanese Black cattle."Animal Science Journal. 74. 383-390 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanazawa, T., Kadowaki, M.: "Regulation of autophagy by amino acids."Eiyo Hyouka to chiryo. 20. 483-486 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kadowaki, M., Kanazawa, T.: "Signaling mechanism of hepatic autophagy."Seitai no Kagaku. 54. 528-533 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanazawa, T.et al.: "Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes."Journal of Biological Chemistry. 279. 8452-8459 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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