2003 Fiscal Year Final Research Report Summary
Efficient Utilization of Fisheries Biproducts. Exploration of miomedial Resoures from Deep-Sea Spong
| Project/Area Number |
14360119
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUSETANI Nobuhiro The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (70012010)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Yoichi The University of Tokyo, Graduate School of Agricultural and Life Sciences, Assistant, 大学院・農学生命科学研究科, 助手 (60282696)
MATSUNAGA Shigeki The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate Professor, 大学院・農学生命科学研究科, 助教授 (60183951)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Deep-Sea / Sponge / Biomedical / Bioactive / Cytotoxic / Structure elucidation |
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| Research Abstract |
In order to explore the possibility of discovering new compounds with biomedical importance from deep-sea sponges, we collected 78 samples at Shinsone, near Oshima Island and examined the biological activities of their extracts. More than 70% of the extracts exhibited either cytotoxic, antimicrobial, or enzyme inhibitory activity, demonstrating the importance of deep-sea sponges in natural products drug discovery. We have isolated the following compounds from the collected specimens.
1.Theopederin K from Discodermia japonica
2.Shinsonefuran from Stoeba extensa
3.Novel macrolides from Poecillastra sp.
Isolation of cytotoxic constituents from another deep-sea sponge collected off Heda, Izu, is in progress.
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