2003 Fiscal Year Final Research Report Summary
The protective roles of IL-18 in host defense against gastro-intestinal nematode infection by in duction of Th2 responses.
| Project/Area Number |
14370086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
YOSHIMOTO Tomohiro Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60241171)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60172350)
TSUTSUI Hiroko Hyogo College of Medicine, Faculty of Medicine, Associate Professor, 医学部, 助教授 (40236914)
YASUDA Koubun Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 助手 (50333539)
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| Project Period (FY) |
2002 – 2003
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| Keywords | IL-18 / Th2 response / mucosal mast cells / mMCP-1 / gastrro-intesinal nematbde / host defense |
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| Research Abstract |
IL-18 enhances the IL-12-deriven Th1 immune responses, but it can also stimulate Th2 immune response in the absence of IL-12. Here we show that IL-18 plus IL-2 treatment of mice induces Th2 cytokines(IL-3,IL-4,IL-9 and IL-13), intestinal mucosal mast cells(MMC) and the release of MMC-specific mouse mast cell protease-1(mMCP-1), resulting in extremely rapid expulsion of adult worms of gastrointestinal nematode Strongyloides venezuelensis(S.venezuelensis). This induction is dependent on CD4+ T cells, but not on stat6. Wild-type mice infected with S.venezuelensis L3 significantly increase in serum levels of IL-18. Furthermore, when IL-18-/-mice are infected with S.venezuelensis L3, worm expulsion is significantly delayed as compared with wild-type mice. These findings establish a role for IL-18 in immunity to gastrointestinal nematode by induction of functional intestinal MMC.
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[Publications] Fujimori, Y., Yoshimoto, T., Matsui, K., Tsutsui, H., Okamoto, T., Kashiwamura, S., Hada, T., Okamura H., Kakishita, E., Hara H., Nakanishi K.: "Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host diseases after alogenic bone marrow transplantation."J.Interferon.Cytokine.Res.. 22. 751-754 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Yoshimoto, T., Min, B., Sugimoto, T., Hayashi, N., Ishikawa, Y., Sasaki, Y., Hata, H., Takeda, K., Okumura, K., Kaer, L.V., Paul, W.E., Nakanishi, K.: "Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to Interleukin 18 treatment of mice."J Exp Med.. 197. 997-1006 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Fujimoto, M., Tsutsui, H., Xinshou, O., Tokumoto, M., watanabe, D., Shima, Y., Yoshimoto, T., Hirakata, H., Kawase, I., Nakanishi, K., Kishimoto, T., Naka, T.: "Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune duseases."Int.Immunol.. 16. 303-314 (2004)
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「研究成果報告書概要(欧文)」より
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[Publications] Okamura, H., Lotze, M.T., Tsutsui, H., Kashiwamura, S-I., Ueda, H., Yoshimoto, T., Nakanishi, K.: "Interleukin-18. [IL-1F4] The cytokine handbook (4^<th> edition),(Thomson, A.W. and Lotze, M.T., eds)"Elsevier Science Ltd., London. 709-733 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Tsutsui, H., Yoshimoto, T., Okamura, H., Akira, S., Nakanishi, K.: "IL-18 and IL-18 Receptor Knockout Mouse. Cytokine Knockouts (Giamila Fantuzzi, eds)"Human Press, Totowa, New Jersey. 303-322 (2003)
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