• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2003 Fiscal Year Final Research Report Summary

Prenatal and postnatal transfer of pesticides to children

Research Project

Project/Area Number 14370118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTohoku University

Principal Investigator

NAKAI Kunihiko  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (00291336)

Co-Investigator(Kenkyū-buntansha) KAMEO Satomi  Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (40312558)
SATOH Hiroshi  Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (40125571)
Project Period (FY) 2002 – 2003
Keywordspesticides / prenatal exposure / low-dose exposure / behavioral sciences / cohort / DDT / endocrine disruptors / breast milk
Research Abstract

Organochlorine pesticides are compounds widespread in the environment due to their persistence and highly lipophilic nature, and they accumulate in biological systems. Newborns are exposed to these organochlorine compounds across the placenta and through breastfeeding. In the present study, several organochlorine pesticides were analyzed in human breast milk and placenta from 20 mothers to identify the major pesticide compounds. This study was performed as part of our prospective cohort study. Healthy pregnant women were recruited with their informed consent at obstetrical wards of two hospitals in Tohoku between January 2001 and September 2003. The study protocol was approved by the Medical Ethics Committee of the Tohoku University Graduate School of Medicine. HCB, β-HCH, oxy-chlordane, cis-nonachlor, trans-nonachlor, p,p'-DOT, p,p'-DDE, dieldrin, and heptachlorepoxide were found from all breast milk samples and placenta samples. The relationship between pesticides in breast milk and the placenta was analyzed to examine the utilization of the placenta as the material for exposure assessment. The results showed that since there were excellent correlations of all major pesticides between breast milk samples and placenta samples, placenta was suggested to be the useful material to estimate the maternal body burden. In addition, the concentrations of some organochlorine pesticides ouch as HCB, oxy-chlordane, and trans-nonachlor, in the placenta samples had significant negative correlations with parity. This finding clearly shows that the mothers eliminate these pesticides during pregnancy and by breastfeeding into their children. The concentrations of oxy-chlordane, nonachlors, dieldrin, and heptachlorepoxide in breast milk samples and placenta samples were correlated with fish consumption ; however, HCB, HCH, and DDE had no association. These results indicated that the contribution of fish consumption to the intake of pesticides depended on the kind of pesticides.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakai K., Satoh H.: "Evelopmental neurotoxicity following prenatal exposures to methylmercury and PCBs in humans from epidemiological studies."Tohoku Journal of Experimental Medicine. 196. 89-98 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arisawa K., Matsumura T., Tohyama C., Saito H., Satoh H., Nagai M., Morita M., Suzuki T.: "Fish intake, plasma ω-3 polyunsaturated fatty acids, and polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans and co-planar polychlorinated biphenyls in the blood of the Japanese population."International Archives of Occupational and Environmental Health. 76. 205-215 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki K., Nakai K., Oka T., Hosokawa T., Okamura K., Sakai T., Satoh H.: "Effects of perinatal exposure to environmentally persistent organic pollutants and chemicals on neurobehavioral development in Japanese children : III. maternal smoking confounds neonatal neurobehavioral status."Organohalogen Compounds. 65. 218-221 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoh H.: "Behavioral teratology of mercury and its compounds."Tohoku Journal of Experimental Medicine. 201. 1-9 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwasaki Y., Sakamoto M., Nakai K., Oka T., Dakeishi M., Iwata T., Satoh H., Murata K.: "Estimation of daily mercury intake from seafood in Japanese women : Akita cross-sectional study."Tohoku Journal of Experimental Medicine. 200. 67-73 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai K., Keita S., Oka T., Murata K., Sakamoto M., Okamura K., Hosokawa T., Takeo S., Nakamura T., Saito Y., Kurokawa N., Kameo S., Satoh H.: "The Tohoku Study of Child Development : A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children."Tohoku Journal of Experimental Medicine. 202(submitted). 227-238 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakai K, Satoh H: "Evelopmental neurotoxicity following prenatal exposures to methylmercury and PCBs in humans from epidemiological studies."Tohoku Journal of Experimental Medicine. 196. 89-98 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arisawa K., Matsumura T., Tohyama C., Saito H., Satoh H., Nagai M., Morita H., Suzuki T.: "Fish intake, plasma ω-3 polyunsaturated fatty acids, and polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans and co-planar polychlorinated biphenyls in the blood of the Japanese population."International Archives of Occupational and Environmental Health. 76. 205-215 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki K., Nakai K., Oka T., Hosokawa T., Okamura K., Sakai T., Satoh H.: "Effects of perinatal exposure to environmentally persistent organic pollutants and chemicals on neurobehavioral development in Japanese children : III. maternal smoking confounds neonatal neurobehavioral status."Organohalogen Compounds. 65. 218-221 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoh H.: "Behavioral teratology of mercury and its compounds."Tohoku Journal of Experimental Medicine. 201. 1-9 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwasaki Y., Sakamoto M., Nakai K., Oka T., Dakeishi M., Iwata T., Satoh H., Murata K.: "Estimation of daily mercury intake from seafood in Japanese women : Akita cross-sectional study."Tohoku Journal of Experimental Medicine. 200. 67-73 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakai K., Keita S., Oka T., Murata K., Sakamoto M., Okamura K., Hosokawa T., Takeo S., Nakamura T., Saito Y., Kurokawa N., Kameo S., Satoh H.: "The Tohoku Study of Child Development : A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children."Tohoku Journal of Experimental Medicine. 2002(Submitted). 27-238 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2005-04-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi