2005 Fiscal Year Final Research Report Summary
Epidemiologic studies on the screening for sleep disordered breathing in relation to cardiovascular diseases.
| Project/Area Number |
14370132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TANIGAWA Takeshi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Department of Public Health Medicine Doctoral Program in Social and Environmental Medicine, Associate Professor, 人間総合科学研究科, 助教授 (80227214)
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| Co-Investigator(Kenkyū-buntansha) |
ISO Hiroyasu Osaka University, Graduate School of Medicine, Public Health Department of Social and Environmental Medicine Division of Preventive and Environmental Medicine, Professor, 大学院・医学系研究科, 教授 (50223053)
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| Project Period (FY) |
2002 – 2005
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| Keywords | Sleep apnea / Sleep disordered breathing / Hypertension / Screening / industrial health / Pulse oximetry / community / Obesity |
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| Research Abstract |
Sleep-disordered breathing (SDB) is a condition of repetitive episodes of decreased or arrested respiratory airflow during sleep. We have conducted several surveys using the pulse-oximetry to detect SDB in working populations and communities. We found that prevalence of SDB among male residents and workers in Japan was similar to that in the US and EU countries.
To examine the relationship between SDB and blood pressure levels among Japanese men, we conducted a population-based cross-sectional study in rural and urban communities men. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB. The multivariate odds ratio of hypertension for the low versus high category of 3% ODI level was 1.63 (95% CI, 1.1-2.5). These associations were more evident among overweight than non-overweight individuals. In addition, we measured ODI by nocturnal pulse-oximetry among male shift workers and male day workers at nuclear power plants in Japan. Systolic and diastolic blood pressure levels were significantly correlated with 3%ODI in total subjects after adjustment for potential confounding variables (p=0.04). This association was primarily observed among workers aged 【greater than or equal】40 years, more specifically older shift workers. A correlation between SDB severity and diastolic blood pressure levels among shift workers aged 【greater than or equal】40 years suggests the importance of screening for SDB among shift workers for blood pressure control.
To clarify the association between usual alcohol consumption and nocturnal oxygen desaturation, we compared ODI levels according to categories of alcohol intake. We found a significant positive association between usual alcohol consumption and the severity of SDB among middle-aged Japanese men, independent of age, BMI and smoking. This association was more evident among non-overweight subjects, indicating the importance of alcohol abstinence for non-overweight SDB patients.
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[Journal Article] 睡眠時無呼吸症候群と産業保健2006
Author(s)
谷川 武, 櫻井 進, 山岸 良匡, 崔 仁哲, 池田 愛, 八尾正之, 野田 博之, 梅澤光政, 池原賢代, 村木功, Terry Young.
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Sleep apnea syndrome and Occupational Health.2006
Author(s)
Tanigawa T, Sakurai S, Yamagishi K, Cei Z, Ikeda A, Yao M, Noda H, Umesawa M, Ikehara S, Muraki I, Terry Y.
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Journal Title
Ind Med Reviews. 19
Pages: 43-72
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 睡眠呼吸障害と血圧.2004
Author(s)
谷川武, 櫻井進, 立花直子, 山岸良匡, 村木功, 工藤美奈子, 大平哲也, 北村明彦, 佐藤眞一, 嶋本喬, 磯博康.
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Book] 東京 : 厚生科学研究所2004
Author(s)
谷川武, 佐藤誠, 中野博, 山元廣治, 中俣正美 著.
Total Pages
14-19, 51-66
Publisher
睡眠時無呼吸症候群スクリーニングハンドブック.(谷川武編)
Description
「研究成果報告書概要(和文)」より
