2003 Fiscal Year Final Research Report Summary
A study of development of susceptibility genes related to modification of a living habit behavior for prevention of lifestyle related diseases.
| Project/Area Number |
14370136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Yamanashi (2003)
山梨医科大学 (2002) |
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Principal Investigator |
YAMAGATA Zentaro University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor, 大学院・医学工学総合研究部, 教授 (10210337)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Yasuhisa University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Associate Professor, 大学院・医学工学総合研究部, 助教授 (60324183)
MIZUTANI Takashi University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Research Associate, 大学院・医学工学総合研究部, 助手 (50334868)
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| Project Period (FY) |
2002 – 2003
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| Keywords | gene polymorphism / behavior / prevention / SNP |
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| Research Abstract |
The purpose of this study is development of susceptibility genes related to modification of living habit behavior for prevention of lifestyle related diseases. We named the gene a behavior modification susceptibility gene. We tried to develop a program for prevention of life-style related diseases.
First, we investigated a association between smoking habit and the CYP2A6 gene polymorphism because nicotine is responsible for smoking dependence and is mainly metabolized by CYP2A6. Several types of genetic polymorphism of CYP2A6 have been reported. We clarified an association between CYP2A6 genotypes and smoking habit, cessation of smoking.
The percentage of subjects with a CYP2A6de1 allele (genotype D) was lower in heavy smokers (22%, n=20) than in light smokers and non smokers (35%, n=40). The frequency of was lower in persons stopped smoking than in persons could not stop smoking.
Trp64Arg mutation in the beta 3-adrenergic receptor (ADRB3) gene is related with obesity but it is not clear that this mutation is associated with reduction of body weight. We investigated the response of reduction of body weight in Japanese men with Trp64Arg mutation in the ADRB3 gene. At the baseline of BMI, there was no significant difference in participants with/without mutation of the ADRB3 gene. The frequency of Trp64Arg is lower in the persons reduced BMI than in the persons could not reduce BMI significantly. The results of this study suggest that the Trp64Arg mutation of the ADRB3 gene is associated with difficulty in reduction of BMI through behavioral intervention.
We tried to develop a program to prevent of life-style related diseases using behavior modification susceptibility gene polymorphisms.
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