| Co-Investigator(Kenkyū-buntansha) |
WATANABE Misuzu WATANABE,Misuzu, 医学部, 助手 (30298624)
TAKAGI Kenji Nagoya University School of Health Sciences, Department of Medical Technology, Associate Professor, 医学部, 助教授 (80126870)
TAKAGI Kenzo Nagoya University School of Health Sciences, Department of Medical Technology, Professor, 医学部, 教授 (50093050)
TSUBOI Hirohito TSUBOI,Hirohito, 医学部, 助手 (20319338)
HON Reiko HON,Reiko, 医学部, 助手 (80329812)
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| Research Abstract |
Blood samples of 90 construction workers were analyzed for hemoglobin-formaldehyde adducts after obtaining their informed consent. The workers were classified into two groups. One was indoor workers group whose main workplace located indoor, consisted with plumbers, interior finish workers, tile layer, plasterer, electric engineer etc. and the other was outdoor group whose main workplace located outdoor, consisted with carpenters, digger, landscape workers, office workers, director in construction site, etc. The mean hemoglobin-formaldehyde adducts concentration of the indoor group was 6.5c0.9 μmol/gHb, and that of the outdoor group was 6.0±1.2 μmol/gHb. The results showed tendency of the higher hemoglobin-formaldehyde adducts concentration among workers who work indoor at house building sites. Though the adduct concentrations reflect the exposure to aldehydes during recent one month, it is difficult to evaluate the exposure. So we planned to conduct the animal study to expose rats to exact concentration of formaldehyde for about one month, but we found the large variability among unexposed rats. This finding made further experiments difficult. The biological monitoring of aldehydes with hemoglobin adducts requires complicated procedure, special formaldehyde-free water and blood sampling. Those are weak points as a screening test to evaluate the exposure to aldehydes of large number of workers. To establish the method of the biological monitoring, we should solve those problems.
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