2003 Fiscal Year Final Research Report Summary
Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.
| Project/Area Number |
14370170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KOBAYASHI Masanobu Institute for Genetic Medicine, Associate Professor, 遺伝子病制御研究所, 教授 (80241321)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takahiko Hokkaido University, Hospital, Instructor, 医学部・歯学部附属病院, 講師 (80333607)
SHINDO Masanobu Hokkaido Graduate School of Dentistry, Associate Professor, 大学院・歯学研究科, 助教授 (20162802)
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| Project Period (FY) |
2002 – 2003
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| Keywords | hypoxia / hypoglycemia / Glucose transporter / pancreatic cancer / angiogenesis / adrenomedullin / adrenomedullin antagonist / glycolysis |
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| Research Abstract |
1)We found that the expression of adrenomedullin, which has been reported to be a vasodilater, is enhanced by hypoxia.
2)We found that the administration of adrenomedullin antagonist peptides into tumor tissues induced the disappearance of tumors through the suppression of angiogenesis.
3)We found that dominant negative HIF-1α decreased the resistance to apoptosis induced by hypoglycemia.
4) We also found that dominant negative HIF-1α decreased the tumorigenicity of a pancreatic cancer cell line.
5)We demonstrated that dominant negative HIF-1α decreased the expression of Glut-1 enhanced by hypoxia and that dominant negative HIF-1α decreased the uptake of FDG in tumor tissues.
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