2004 Fiscal Year Final Research Report Summary
Develpoment of Diagnositic System for Cancer Metastases Utilizing Fluoroscopic Endoscope
| Project/Area Number |
14370372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUYAMA Shoji Tohoku University, Hospital, Assistant, 病院, 助手 (10344673)
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| Co-Investigator(Kenkyū-buntansha) |
SUNAMURA Makoto Tohoku University, Hospital, Lecturer, 病院・講師 (10201584)
EGAWA Shinichi Tohoku University, Hospital, Assistant, 病院・助手 (00270679)
TAKEDA Kazunori Tohoku University, Graduate School of Medicine, Assistant Professor, 大学院・医学系研究科, 助教授 (20171639)
MATSUNO Seiki Tohoku University, Graduate School of Medicine, professor, 大学院・医学系研究科, 教授 (80004737)
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| Project Period (FY) |
2002 – 2004
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| Keywords | cancer / laparoscopic surgery |
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| Research Abstract |
Despite recent development of a number of combined therapeutic approaches, the prognosis for pancreatic cancer is still extremely poor. Although, there are options of chemotherapies of Gemzar, 5-FU or other agents, an effective protocol has not been established yet. 5-FU is popular, however, the effective rate is 15-20%. Consequently, new treatment system including diagnosis is necessary to be developed.
We developed a new diagnostic system using mutant replication-selective adenovirus encoding the green fluorcent protein (GFP). The purpose of this study is to assess the effect of develop the new gene diagnostic system by the utilizing videoscope. Furthermore, we used a selectively replication-competent adenovirus that can multiply only in abnormal p53 gene cells to induce the higher expression of GFP genes. This adenovirus can infect also the adjacent non-infected cancer cells, overcoming limitation of the transfer efficacy by a replication-incompetent virus. Three pancreatic cancer cell lines infected with the adenovirus encoding the GFP gene changed its fluorecence. These results strongly suggested that GFP gene diagnostic system is effective for intra-operative diagnosis of pancreatic cancer and using mutant adenovirus make this strategy much stronger.
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[Journal Article] The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism2004
Author(s)
Rubino, F., Gagner, M., Gentileschi, P., Kini, S.Fukuyama, S.Feng, J.Diamond, E
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Journal Title
Ann Surg. 240(2)
Pages: 236-242
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Dual endoscopic-assisted endoluminal colostomy reversal : a feasibility study.2004
Author(s)
Jacob, B.P., Gagner, M,.Hung, T.I., Fukuyama S, Waage, A., Biertho, L., Kim, W.W., Sekhar, N
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Journal Title
Surg Endosc 18(3)
Pages: 433-439
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Laparoscopic harvesting of small bowel graft for small bowel transplantation2002
Author(s)
Kim, W.W., Gagner, M., Fukuyama, S., Hung, T.I., Biertho, L., Jacob, B.P., Gentileschi, P.
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Journal Title
Surg Endosc 16(12)
Pages: 1786-1789
Description
「研究成果報告書概要(欧文)」より
