2004 Fiscal Year Final Research Report Summary
Selection of Surrogate Marker Genes in Malignant Brain Tumor to Advanced Therapy by DNA Array Analysis of Gene Expression Profiles
| Project/Area Number |
14370428
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
YAMANAKA Ryuya Niigata University, Brain Research Institute, Lecturer, 脳研究所, 講師 (20323991)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Ryuichi Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (30018816)
TAKAHASHI Hideaki Niigata University, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 (70236305)
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| Project Period (FY) |
2002 – 2004
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| Keywords | malignant brain tumor / Gene expression profile / Gene Chip / Immunotherapy / Chemotherapy |
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| Research Abstract |
Glioblastoma, anaplastic glioma(Grade III), low grade glioma, primary central nervous
system lymphoma and normal brain samples were studied (total of 100 samples) using cDNA microarray technology. The phylogenetic tree resulting from the hierarchical clustering algorithm have employed. Fifty genes were selected as specific molecular targeted genes in glioblastoma and primary central nervous system lymphoma.
In conclusion, accumulation of data with respect to expression profiles of malignant brain tumor specimens, clinico-pathological data, susceptibility to treatment, and outcome will bring us information for identifying optimized therapeutic modalities for individual patients and novel therapeutic targets.
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