2003 Fiscal Year Final Research Report Summary
Induction of anti-tumor immunity by intracellular hyperthermia using magnetite
| Project/Area Number |
14370430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University |
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Principal Investigator |
WAKABAYASHI Toshihiko Nagoya University, University Hospital, Associate Professor, 医学部附属病院, 助教授 (50220835)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Jun Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (40158449)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Hyperthermia / Magnetite / Brain tumor / Liposome / Anti-tumor immunity / HSP70 / Magnetic field |
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| Research Abstract |
Magnetite particles of nanometer size are involved in an increasing number of biological and medical applications. The unique feature of magnetite particles is their reaction to a magnetic force. Hysteresis loss in the alternative magnetic field is a very important feature of magnetic particles, because it enables effective hyperthermia. Using magnetite cationic liposomes (MCLs), induction of antitumor immunity to glioma by intracellular hyperthermia was investigated in the central nervous system. MCLs, which have a positive surface charge, were used as heating mediators for intracellular hyperthermia. T-9 rat glioma tissue was formed subcutaneously on femur of female F344 rats, and MCLs was injected into the tumor mass. After that, the rats were received irradiation with an alternating magnetic field (AMP). As a result, the pathological investigation demonstrated effectiveness in attacking glioma immunologically even in the brain and significant prolonging of the survival time. In conclusion, this method of hyperthermic treatment may induce antitumor immunity and can effect on glioma even in the central nervous system as an antitumor vaccination.
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[Publications] Wakabayashi T, Nakahara K, Kunimoto K, Fujii M, Hatano H, Ohno T, Yoshida J, Ito A, Shinkai M, Honda H, Kobayashi T, Takemura A: "Intracellular hyperthermia by means of magnetoliposome."Publisher in Kyusyu Univ Press. 493-496 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takasu S, Takahashi T, Okamoto S, Oriuchi N, Nakayashiki N, Okamoto K, Muramatsu H, Hayashi T, Nakahara N, Mizuno M, Wakabayashi T, Higuchi T, Endo K, Kozaki K, Miyaishi O, Saga S, Ueda R, Yoshida J, Yoshikawa K: "Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor"J Neuro-Oncol. 63. 247-256 (2003)
Description
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