2005 Fiscal Year Final Research Report Summary
Development of new prostheses for arthroplasty with an added ability to promote bone repair using bone morphogenetic protein (BMP)
| Project/Area Number |
14370459
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
SAITO Naoto Shinshu University, School of Medicine, Professor, 医学部, 教授 (80283258)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Seneki Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (40205464)
SHIMIZU Tominaga Shinshu University, School of Medicine, Assistant Professor, 医学部, 講師 (40283270)
MURAKAMI Narumichi Shinshu University, University Hospital, Assistant, 医学部附属病院, 助手 (50334892)
TAKAHASHI Jun Shinshu University, University Hospital, Assistant, 医学部附属病院, 助手 (60345741)
TAKAOKA Kunio Osaka City University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (30112048)
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| Project Period (FY) |
2002 – 2005
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| Keywords | bone morphogenetic protein / prosthesis for arthroplasty / bone tissue repair / drug delivery system / biomaterial / cytokine / mononuclear cell / biodegradable polymer |
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| Research Abstract |
In order to developing new prostheses for arthroplasty with an added ability to promote bone repair using bone morphogenetic protein (BMP), we first developed a safe new BMP delivery system using PLA-DX-PEG, a biodegradable polymer. This polymer is suitable for incorporating BMP and constructing a prosthetic device. The prosthesis constructed from this BMP/PLA-DX-PEG composite was then used for experimental hip replacement in an animal model to confirm the usefulness of this device. However, many problems related to BMP itself remain to be resolved before clinical application of this prosthesis containing BMP. In humans, insufficient bone formation is obtained with small volumes of BMP, which makes a large quantity of BMP necessary. However, BMP is expensive. To resolve this problem, we studied the application of PTH or pentoxifylline, either of which can improve the bone induction ability of BMP. Next, we tried bone marrow mononuclear cell transplantation to improve blood flow in tissue surrounding the area undergoing bone repair. The new prosthetic material that we developed showed a high affinity to bone, and a potent ability to improve bone repair using BMP. The compositions of conventional prosthetic materials and this new material are currently being studied in order for this new material to be effectively incorporated into a prosthesis containing BMP. From improving the ability of BMP to promote bone repair to the development of new materials to construct the prosthesis, we developed a general technology for new prostheses for arthroplasty with an added ability to promote bone repair using BMP. We consider it necessary to promote more multidirectional approaches to the clinical application of BMP.
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[Journal Article] Trabecular minimodeling in human iliac bone2003
Author(s)
Kobayashi S, Takahashi HE, Ito A, Saito N, Nawata M, Horiuchi H, Ohta H, Ito A, Iorio R, Yamamoto N, Takaoka K
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption2003
Author(s)
Nakamura M, Udagawa N, Matsuura S, Mogi M, Nakamura H, Horiuchi H, Saito N, Hiraoka Y, Kobayashi Y, Takaoka K, Ozawa H, Miyazawa H, Takahashi N
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Journal Title
Endocrinology 144
Pages: 5441-5449
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Trabecular minimodeling in human iliac bone.2003
Author(s)
Kobayashi S, Takahashi HE, Ito A, Saito N, Nawata M, Horiuchi H, Ohta H, Ito A, Iorio R, Yamamoto N, Takaoka K.
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption.2003
Author(s)
Nakamura M, Udagawa N, Matsuura S, Mogi M, Nakamura H, Horiuchi H, Saito N, Hiraoka Y, Kobayashi Y, Takaoka K, Ozawa H, Miyazawa H, Takahashi N.
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Journal Title
Endocrinology 144
Pages: 5441-5449
Description
「研究成果報告書概要(欧文)」より
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[Book] New synthetic biodegradable polymers for bone morphogenetic protein delivery systems. In : Tissue engineering and novel delivery systems(Yaszemski MJ, Trantolo DJ, Lewandrowski KU, Hasirci V, Altobelli DE, Wise DL(eds))2004
Author(s)
Saito N, Horiuchi H, Murakami N, Takahashi J, Okada T, Nozaki K, Takaoka K
Total Pages
645, 475-482
Publisher
Marcel Dekker inc., New York
Description
「研究成果報告書概要(和文)」より
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[Book] Tissue engineering and novel delivery systems (Yaszemski MJ, Trantolo DJ, Lewandrowski KU, Hasirci V, Altobelli DE, Wise DL (eds))2004
Author(s)
Saito N, Horiuchi H, Murakami N, Takahashi J, Okada T, Nozaki K, Takaoka K
Total Pages
475-482
Publisher
Marcel Dekker inc., New York
Description
「研究成果報告書概要(欧文)」より
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