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2004 Fiscal Year Final Research Report Summary

Role of endocannabinoid in circulatory and nociceptive regulation systems

Research Project

Project/Area Number 14370494
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKitasato University

Principal Investigator

HOKA Sumio  Kitasato University, School of Medicine, Professor, 医学部, 教授 (60150447)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Hirotsugu  Kitasato University, School of Medicine, Associate Professor, 医学部, 助教授 (50224077)
ARAI Masayasu  Kitasato University, School of Medicine, Assistant Professor, 医学部, 講師 (50222724)
ARAI Tamie  Kitasato University, School of Medicine, Research Associate, 医学部, 助手 (00245408)
Project Period (FY) 2002 – 2004
Keywordscannabinoid / nociception / microcirculation / inflammation / leukocyte / migration / adhesion / pain control
Research Abstract

This study was designed to investigate possible roles of cannabinoid agonists and antagonists in circulatory and nociceptive regulation systems in the body. For this purpose we examined the effects of cannabinoid agonists and antagonists on neutrophil behaviors in response to inflammatory stimulation. The neutrophil behavior was observed in the microvasculature of hamster cheek pouch using a trans-illumination microscope. Superfusion of lekotrience B_4 caused an increase in the number of neutrophils adhering the endothelium and migrating through the endothelium outside the venules. The migration induced by lekotrience B_4 was significantly attenuated in hamsters receiving intravenous infusion of WIN55212, a cannabinoid agonist, prior to the leukotriene B_4 superfusion. These effects were abolished by AM251 and AM630, cannabinoid antagonists. These results suggest that augmentation of the cannabinoid system could produce an inhibition of neutrophil migration and contribute to suppression of inflammatory derangement and hyperalgesia.

  • Research Products

    (19 results)

All 2005 2004 2003 2002 Other

All Journal Article (19 results)

  • [Journal Article] 内因性カンナビノイドの役割2005

    • Author(s)
      外 須美夫
    • Journal Title

      臨床麻酔 29

      Pages: 159-165

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Migration of neutrophils elicited by leukotriene B_4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch.2004

    • Author(s)
      Ozawa A et al.
    • Journal Title

      Circulation Control 25

      Pages: 267-271

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Intrathecal Mepivacaine and prilocaine are loss neurotosic than lidocaine in a rat inpathecal model2004

    • Author(s)
      Takenami T et al.
    • Journal Title

      Reg Anesth.Pain Med. 29

      Pages: 446-453

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Faster oscillometric manometry does not sacrifice the accuracy of blood pressure determination.2004

    • Author(s)
      Sugimachi, M., Okamoto, H., Hoka, S., Sunagawa, K.
    • Journal Title

      Blood Press Monit 9

      Pages: 135-141

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Altered bupivacaine pharmacokinetics by MgSO4 in rats.2004

    • Author(s)
      Okutomi, T., Saito, M., Matsumoto, Y., Shimizu, M., Fukuoka, M., Hoka, S.
    • Journal Title

      Can J Anaesth 51

      Pages: 93-94

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch.2004

    • Author(s)
      Ozawa, A., Nara, Y., Kimotsuki, H., Nakahara, E., Okamoto, H., Hoka, S.
    • Journal Title

      Circ Cont 25

      Pages: 267-271

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of dexmedetomidine on transient cerebral ischemia in rats.2004

    • Author(s)
      Kimotsuki, H., Okamoto, H., Ozawa, A., Hoka, S.
    • Journal Title

      Circ Cont 25

      Pages: 50-55

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model.2004

    • Author(s)
      Takenami, T., Yagishita, S., Nara, Y., Hoka, S.
    • Journal Title

      Reg Anesth Pain Med 29

      Pages: 446-453

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Quantitative analysis of left ventricular regional wall motion with color kinesis during abdominal aortic cross-clamping.2003

    • Author(s)
      Yamaura K et al.
    • Journal Title

      J.Cardiothorac.Vasc.Anesth. 17

      Pages: 703-708

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 麻酔中の前負荷指向型循環管理2003

    • Author(s)
      外 須美夫
    • Journal Title

      臨床麻酔 27

      Pages: 1895-1902

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Quantitative analysis of left ventricular regional wall motion with color kinesis during abdominal aortic cross-clampi.2003

    • Author(s)
      Yamaura, K., Hoka, S., Okamoto, H., Takahashi, S.
    • Journal Title

      J Cardiothorac Vasc Anesth 17

      Pages: 703-708

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats.2003

    • Author(s)
      Yamaguchi-Sase, S., Hayashi, I., Okamoto, H., Nara, Y., Matsuzaki, S., Hoka, S., Majima, M.
    • Journal Title

      Inflamm Res 52

      Pages: 164-169

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Overexpression of Ca2+-permeable AMPA receptor promotes delayed cell death of hippocampal CA1 neurons following transient forebrain ischemia.2003

    • Author(s)
      Anzai, T., Tsuzuki, K., Yamada, N., Hayashi, T., Iwakuma, M., Inada, K., Kameyama, K., Hoka, S., Saji, M.
    • Journal Title

      Neurosci Res 46

      Pages: 41-51

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intrathecal lidocaine causes posterior root axonal degeneration near entry into the spinal cord in rats.2002

    • Author(s)
      Takenami, T., Yagishita, S., Arai, M., Asato, F., Hoka, S.
    • Journal Title

      Reg Anesth Pain Med 27

      Pages: 58-67

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of kinin and prostaglandin in cutaneous thermal nociception.2002

    • Author(s)
      Matsuzaki, S., Hayashi, I., Nara, Y., Komata, K., Yamanaka, M., Okamoto, H., Hoka, S., Majima, M.
    • Journal Title

      Int Immunopharmacol 2(13-14)

      Pages: 2005-2012

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intrathecal fentanyl/meperidine combined with low-dose epidural bupivacaine for Cesarean section in a patient with advanced Krukenberg tumors.2002

    • Author(s)
      Okutomi, T., Hoshino, Y., Amano, K., Okamoto, H., Hoka, S.
    • Journal Title

      Acta Anaesthesiol Scand 46

      Pages: 1272-1275

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Continuous spinal analgesia for labor and delivery in a parturient with hypertrophic obstructive cardiomyopathy.2002

    • Author(s)
      Okutomi, T., Kikuchi, S., Amano, K., Okamoto, H., Hoka, S.
    • Journal Title

      Acta Anaesthesiol Scand 46

      Pages: 329-331

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Porcine Fas-ligand gene : genomic sequence analysis and co Smparison with human gene.2002

    • Author(s)
      Motegi-Ishiyama, Y., Nakajima, Y., Hoka, S., Takagaki, Y.
    • Journal Title

      Mol Immunol 38

      Pages: 581-586

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Beware of gastric tube!

    • Author(s)
      Kondo, Y.J., Okutomi, T., Hoka, S.
    • Journal Title

      Anesth Analg 95

      Pages: 1122

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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