2005 Fiscal Year Final Research Report Summary
Angiogenesis and tumor dormancy therapy in gynecological cancer
| Project/Area Number |
14370528
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gifu University |
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Principal Investigator |
FUJIMOTO Jiro Gifu University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (80199372)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAYA Teruhiko Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70079870)
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| Project Period (FY) |
2002 – 2005
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| Keywords | gynecological cancers / metastasis / angiogenesis / angiogenic factor / transcription factor / angiogenic inhibitor / tumor dormancy therapy |
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| Research Abstract |
Each gynecological cancer conserves specific expression manners of angiogenic factors and of the angiogenic transcription factor ETS-1 to promote specific secondary spreading. The keys to creating new strategies of anti-angiogenic therapy are : (1) The overexpression of TP linked to ETS-1 in metastatic lymph nodes of uterine cervical cancers ; (2) The signal switching from VEGF to bFGF linked to ETS-1 with dedifferentiation of uterine endometrial cancers ; and (3) The overexpression of VEGF linked to ETS-1 in peritoneal dissemination of ovarian cancers. We are looking forward to proceeding with clinical trials of anti-angiogenic agents in advanced-stage patients and after curative resection for gynecological cancers.
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