2003 Fiscal Year Final Research Report Summary
The molecular analyses of Cadherin-11 and periostin regulating osteoblast differentiation
| Project/Area Number |
14370590
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KUDO Akira Tokyo Institute of Technology, Guraduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授 (70178002)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Keiji The University of Tokushima, School of Dentistry, Professor, 歯学部, 教授 (20262206)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Cadherin-11 / Osteo-linegae / Teratoma / mesenchymal cells / 骨芽細胞 / ペリオスチン / メカニカルストレス |
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| Research Abstract |
We studied Cadherin-11 function in the differentiation of osteoblasts.
Teratomas harbouring the Cadherin-11 gene generated bone and cartilage preferentially. Cadherin-11 transfectants of C2C12 cells and Cadherin-11 and/or N-cadherin transfectants of L cells demonstrated that Cadherin-11.
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[Publications] Kashima, T., Nakamura, K., Kawaguchi, J., Takanashi, M., Ishida, T., Aburatani, H., Kudo, A.et al.: "Overexpression of cadherins suppresses pulmonary metastasisi of osteosarucoma in vivo."Int.J.Cancer:. 104. 147-154 (2003)
Description
「研究成果報告書概要(和文)」より
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[Publications] Hirose, Y., Suzuki, H., Amizuka, N., Shimomura, J., Kawano, Y., Nozawa-Inoue, K., Kudo, A., Maeda, T.: "Immunohistochemical localization of periostin in developing long bones of mice."Biomedical Res.. 24. 31-37 (2003)
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「研究成果報告書概要(和文)」より
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[Publications] Oshima, A., Tanabe, H., Yan, T., Lowe, G.N., Glackin, C.A., Kudo, A.: "A nobel mechanism for the regulation of osteoblast differentiation. : Transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, Twist."J.Cell.Biochem.. 792-804 (2002)
Description
「研究成果報告書概要(和文)」より
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