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2004 Fiscal Year Final Research Report Summary

Neuroscientific studies on brain mechanisms of affective behavior, learning and memory of taste.

Research Project

Project/Area Number 14370593
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Takashi  Osaka University, Graduate School of Human Sciences, Professor, 人間科学研究科, 教授 (60028793)

Co-Investigator(Kenkyū-buntansha) SHIMURA Tsuyoshi  Osaka University, Graduate School of Human Sciences, 人間科学研究科, 助教授 (80150332)
INUI Tadashi  Osaka University, Graduate School of Human Sciences, Res.Associate, 人間科学研究科, 助手 (40324735)
MURAKAMI Hideaki  Osaka University, Graduate School of Dentistry, Assistant Professor, 歯学研究科, 助教授 (00263301)
INOUE Tomio  Shouwa University, School of Dentistry, Professor, 歯学部, 教授 (70184760)
Project Period (FY) 2002 – 2004
Keywordstaste / brain / preference / aversion / learning / imaging
Research Abstract

The purpose of the present research project was to reveal brain substances activated by taste stimuli and to show plastic changes of responsiveness of neurons by those substances in rats. The experiments on humans aims to disclose brain functions about taste quality processing and hedonic evaluation of taste with the use of non-invasive brain imaging techniques. The following results were obtained :
1)Brain mechanisms of taste preference learning : Injections of a dopamine D1 receptor antagonist or a glutamine receptor antagonist into the ventral pallidum decreased saccharin intake, while a opioid receptor antagonist increased saccharin intake.
2)Microdialysis study : Brain histamine release was increased by quinine, but no release by sucrose or saccharin, indicating that histamine release was related aversive taste.
3)Brain mechanisms of taste aversion learning : Injections of bicuculline, GABA receptor antagonist, into the ventral pallidum in the rat trained to reject saccharin attenuated aversions to saccharin.
4)Non-invasive brain imaging study : Magnetic response of the brain was greater to simultaneous simulation of odor and visual image when delivered matched than mismatched.

  • Research Products

    (14 results)

All 2005 2004 2003 2002

All Journal Article (13 results) Book (1 results)

  • [Journal Article] Effects of midazolam on the expression of conditioned taste aversion in rats2005

    • Author(s)
      Y.Yasoshima, T.Yamamoto
    • Journal Title

      Brain Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Centrifugal inputs modulate taste aversion learning associated parabrachial neuronal activities2004

    • Author(s)
      K.Tokita, T.Yamamoto et al.
    • Journal Title

      Journal of Neurophysiology 92・1

      Pages: 265-279

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Centrifugal inputs modulate taste aversion learning associated parabrachial neuronal activities.2004

    • Author(s)
      K.Tokita, Z.Karadi, T.Shimura, T.Yamamoto
    • Journal Title

      Journal of Neurophysiology 92(1)

      Pages: 265-279

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The effect of taste stimuli on histamine release in the anterior hypothalamus of rats.2003

    • Author(s)
      Y.Treesukosol, T.Ishizuka, T.Yamamoto, A.Yamatodani
    • Journal Title

      Brain Research 964(1)

      Pages: 51-55

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A comparison of voluntary salt-intake behavior in Nax-gene deficient and wild-type mice with reference to peripheral taste inputs.2003

    • Author(s)
      U.Watanabe, T.Shimura, N.Sako, J.Kitagawa, T.Shingai, E.Watanabe, M.Noda, T.Yamamoto
    • Journal Title

      Brain Research 967(1-2)

      Pages: 247-256

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Magenetoencephalographic study of cortical activity evoked by electrogustatory stimuli.2003

    • Author(s)
      C.Yamamoto, S.Takehara, K.Morikawa, S.Nakagawa, M.Yamaguchi, S.Iwaki, M.Tonoike, T.Yamamoto
    • Journal Title

      Chemical Senses 28(3)

      Pages: 245-251

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synergistic responses of the chorda tympani to mixtures of umami and sweet substances in rats.2003

    • Author(s)
      N.Sako, K.Tokita, T.Sugimura, T.Yamamoto
    • Journal Title

      Chemical Senses 28(3)

      Pages: 261-266

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Amiloride-insensitive currents of the acid-sensing ion chanel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel.2003

    • Author(s)
      S.Ugawa, T.Yamamoto, T.Ueda, Y.Ishida, A.Inagaki, M.Nishigaki, S.Shimada
    • Journal Title

      Journal of Neuroscience 23(9)

      Pages: 3616-3622

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Altered taste function in mice deficient in the 65-kDa isoform of glutamate decarboxylase.2003

    • Author(s)
      T.Shimura, U.Watanabe, Y.Yanagawa, T.Yamamoto
    • Journal Title

      Neuroscience Letters 356(3)

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Parabrachial unit activities after the acquisition of conditioned taste aversion to a nonpreferred HCI solution in rats.2002

    • Author(s)
      T.Shimura, K.Tokita, T.Yamamoto
    • Journal Title

      Chemical Senses 27(2)

      Pages: 153-158

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The hardness of food plays an important role in food selection behavior in rats.2002

    • Author(s)
      N.Sako, K.Okamoto, T.Mori, T.Yamamoto
    • Journal Title

      Behavioral Brain Research 133(2)

      Pages: 377-382

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Ventral tegmental lesions reduce overconsumption of normally preferred taste fluid in rats.2002

    • Author(s)
      T.Shimura, Y.Kamada, T.Yamamoto
    • Journal Title

      Behavioral Brain Research 134(1-2)

      Pages: 123-130

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Central orexin facilitates gastric relaxation and contractility in rats.2002

    • Author(s)
      M.Kobashi, Y.Furudono, R.Matsuo, T.Yamamoto
    • Journal Title

      Neuroscience Letters 332(3)

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 「おいしい」となぜ食べすぎるのか 味と体のふしぎな関係2004

    • Author(s)
      山本 隆
    • Total Pages
      1-235
    • Publisher
      PHP研究所
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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