Molecular Analysis in Temporomandibular disorder

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14370668
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: KYOTO UNIVERSITY
• Principal Investigator: MURAKAMI Kenichiro Kyoto University, Graduate School of Medicine, Associate Prof., 医学研究科, 助教授 (00174269)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Akira Kyoto University, Graduate School of Medicine, Prof., 医学研究科, 教授 (00162694) ; YASUDA Shinya Kyoto University, Graduate School of Medicine, Assistant Prof., 医学研究科, 助手 (50263075) ; TAKAHASHI Katsu Kyoto University, Graduate School of Medicine, Assistant Prof., 医学研究科, 助手 (90314202) ; SUGAI Manabu Kyoto University, Graduate School of Medicine, Assistant Prof., 医学研究科, 助手 (90303891) ; YAMAMURA Isao Kyoto University, Graduate School of Medicine, Assistant Prof., 医学研究科, 助手 (90332733)
• Project Period (FY): 2002 – 2003
• Keywords: Temporomandibular joint / gene diagnosis / ANKH / 遺伝要因

Research Abstract

(A)Analysis of ank(progressive ankylosis) mouse
The TMJ(temporomandibular join)t of ank mouse was observed in one, two, three, four, five and six months. Mild synovitis was shown in TMJ, while severe ankylosis in other joints. Arthritis in TMJ was demonstrated in ank mouse.
(B)Polymorphic analysis of ANKH gene in TMD(temporomandibular disorder) patients
Human gene analysis in in TMD patients was approved by the medical ethics committee of Kyoto University on December 9, 2001 (#G86). As to ANK-OR and ANK-TR, which were recently reported (Florence WL, 2003 ) case-control study was done in about 80 cases. These involved clicking(16 cases), intermittent lock(13 cases) and closed lock(36 cases).

Research Products

• [Journal Article] Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome (2005)
  • Author(s): Tanioka M., Takahashi K., Murakami K.etc
  • Journal Title: Arch. Dermatol. Res. 296 Pages: 303-308
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome. (2005)
  • Author(s): Tanioka, M., Takahashi, K., Kosugi, S., Kawabata, T., Nishigori C., Miyachi, Y., Iizuka, T.
  • Journal Title: Arch.Dermatol.Res. 296(7) Pages: 303-308
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Outcomes of 152 temporomanudibular joints following arthroscopic anterolateral capsular released by holmium : YAG laser or electrocautery (2004)
  • Author(s): Kaneyama.K., Murakami KI etc
  • Journal Title: Oral Surg Oral Med Oral Pathol 97.5 Pages: 546-551
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synovial chondromatosis of the temporomandibular joint ; clinical and imunohistopathological considerations (2004)
  • Author(s): S.Fujita., K.Murakami etc.
  • Journal Title: Br.J.Oral Maxillofac Surgery 42・3 Pages: 259-260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] In vitro induction of adult hepatic progenitor cells into insulin-producing cells (2004)
  • Author(s): Nakajima-Nagata.N., Sugai M etc
  • Journal Title: Biochem Biophys Res Com 318・3 Pages: 625-630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of Id proteins in B lymphocyte activation : new insights from knockout mouse studies (2004)
  • Author(s): Sugai M.etc
  • Journal Title: J Mol.Med 82・9 Pages: 592-599
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 顎関節症を伴った小下顎症に対しPCRの発現を制御すべく骨延長術を行った一例 (2004)
  • Author(s): 清水巌, 高橋真, 村上賢一郎etc
  • Journal Title: 日顎変形誌 14 Pages: 75-82
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Outcomes of 152 temporomandibular joints following arthroscopic anterolateral capsular release by holmium : YAG laser or electrocautery. (2004)
  • Author(s): Kaneyama K, Segami N, Sato J, Murakami K, Iizuka T.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 97(5) Pages: 546-551
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synovial chondromatosis of the temporomandibular joint : clinical and immunohistopathological considerations. (2004)
  • Author(s): Fujita S, Yoshida H, Tojyo I, Wada T, Murakami K, Iizuka T.
  • Journal Title: Br J Oral Maxillofac Surg. 42(3) Pages: 259-260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vitro induction of adult hepatic progenitor cells into insulin-producing cells. (2004)
  • Author(s): Nakajima-Nagata N, Sakurai T, Mitaka T, Katakai T, Yamato E, Miyazaki J, Tabata Y, Sugai M, Shimizu A.
  • Journal Title: Biochem Biophys Res Commun. 318(3) Pages: 625-630
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of Id proteins in B lymphocyte activation : new insights from knockout mouse studies. (2004)
  • Author(s): Sugai M, Gonda H, Nambu Y, Yokota Y, Shimizu A.
  • Journal Title: J Mol Med. 82(9) Pages: 592-599
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 顎関節診断・治療マニュアル (2003)
  • Author(s): 村上賢一郎
  • Total Pages: 217
  • Publisher: 永末書店
  • Description: 「研究成果報告書概要(和文)」より