2003 Fiscal Year Final Research Report Summary
Probiotics for the preventive dentistry and oral infectious Deseases
| Project/Area Number |
14370706
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | National Institute of Public Health |
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Principal Investigator |
HANADA Nobuhiro National Institute of Public Health, Oral health, Director, 口腔保健部, 部長 (70180916)
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| Co-Investigator(Kenkyū-buntansha) |
SENPUKU Hidenobu National Institute of Infectious Diseases, Bacteriology, Chief, 細菌第1部, 室長 (20250186)
TSURUMOTO Akihisa Tsurumi University, Preventive Dentistry, Professor, 歯学部, 教授 (90188649)
ANDO Yuichi National Institute of Public Health, Oral Health, Chief, 口腔保健部, 室長 (80168046)
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| Project Period (FY) |
2002 – 2003
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| Keywords | dental caries / mutans streptococci / probiotics |
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| Research Abstract |
Oral streptococci, which play an important role in human tooth caries, are called the mutans streptococci and include S.mutans and S.sobrinus. When searching for a pathogenesis control method, effective measures are needed for the three phases of eliminating contagion sources, blocking the infection route, and lowering host susceptibility. Immunological control methods for these bacteria are numerous, including tooth caries vaccination. We conducted a clinical test using a passive immunity method in which teeth were coated with a specific antibody. In this process, the results suggested that physiochemical control methods are more effective than specific antibodies against biofilm produced by Mutans streptococci infecting the tooth surface.
Based on this finding, we developed the probiotics method to eliminate the mutans streptococci using Streptococcus faecalis strain 129BI03B. Streptococcus faecalis inhibit the growth of the mutans streptococci. However, to effectively eliminate the mutans streptococci from oral cavity, we need to inhibit initial adhesion stage of the mutans streptococci. Therefore, Streptococcus faecalis is effective against planktonic bacteria that attach to the teeth surface and form a micro colony.
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[Journal Article] Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte.2003
Author(s)
Nakao R, Hanada N, Asano T, Hara T, Abdus Salam M, Matin K, Shimazu Y, Nakasone T, Horibata S, Aoba T, Honda M, Amagasa T, Senpuku H.
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Journal Title
Immunology 109
Pages: 271-282
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of human interleukin-18 and interleukin-12 treatment on human lymphocyte engraftment in NOD-scid mouse.2002
Author(s)
Senpuku H, Asano T, Matin K, Salam MA, Tsuha Y, Horibata S, Shimazu Y, Soeno Y, Aoba T, Sata T, Hanada N, Honda M.
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Journal Title
Immunology 107
Pages: 232-242
Description
「研究成果報告書概要(欧文)」より
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