2004 Fiscal Year Final Research Report Summary
Development of novel "patient-tailored DDS"by plasma technique
| Project/Area Number |
14370730
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
KUZUYA Masayuki Gifu Pharmaceutical University, Pharmacy, Professor, 薬学部, 教授 (10082984)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Shin-ichi Gifu Pharmaceutical University, Pharmacy, Assistant Professor, 薬学部, 助教授 (90240944)
SASAI Yasushi Gifu Pharmaceutical University, Pharmacy, Assistant Fellow, 薬学部, 助手 (60336633)
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| Project Period (FY) |
2002 – 2004
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| Keywords | plasma treatment / patient-tailored DDS / time-controlled DDS / intragastric floating DDS / drv orocess / crosslinking reaction / controlled release / oral drug delivery |
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| Research Abstract |
Although oral delivery is convenient to administration and acceptable for patients, the therapeutic effects often depend on the each patient's gastrointenstinal (GI) environment. Therefore, the "Patient-Tailored Drug Delivery System (DDS)" should be developed and administered based on the diagnosis of each patient's GI environment. We have studied plasma-assisted preparation of time-controlled DDS and intragastric floating DDS (FDDS) leading to the "Patient-Tailored DDS" targeting the GI tract. Double-compressed tablets composed of drug tablet as a core material and polymer powder, which was used as pharmaceutical aids, as a wall material was prepared to fabricate time-controlled DDS and inttragastric FDDS.
Since plasma-crosslinkable acrylic monomers are one of the component polymers in Eudragits L100-55, argon plasma-irradiation would lead to the suppression of Eudragit L100-55 solubility even in a dissoluble pH-value solution due to the occurrence of the surface cross-link reactions.
… More
When Eudragit L100-55 is used as a wall material of the double-compressed tablet, the initial drug release could be completely sustained for a certain period of time. The lag-time could be controlled by plasma operational conditions.
We have obtained the intragastric FDDS by plasma-irradiation when the double-compressed tablet was prepared using the outer layer to trap evolved carbon dioxide. The double-compressed tablet was prepared using methyl vinyl ether-maleic anhydride copolymer (VEMA), and a mixture of VEMA and hydroxypropyl methylcellulose phthalate as an outer layer. It was found that the tablet plasma-irradiated remains buoyant in the simulated gastric fluids for a prolonged period of time, and the drug release is considerably suppressed. The drug release can be controlled at a desired rate from the tablets by selecting the plasma operational tunings.
The present results have clearly shown that one can prepare a variety of desired DDS devices, if one selects the tailored-polymers for wall materials of double-compressed tablets as well as plasma operational conditions. Less
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