2003 Fiscal Year Final Research Report Summary
Development of the method to diagnose the prognosis of autoimmune disease by clarifying the pathologic factors.
| Project/Area Number |
14370795
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
IWATANI Yoshinori Osaka Univ., Osaka Univ. Graduate School of Medicine, Professor, 医学系研究科, 教授 (60168581)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | autoimmune / thyroid / deep vein thrombosis / CD25+CD4+ cells / CD25+CD8+ cells / CD50+CD8+ cells / IgG3-secreting cells / interleukin-10 (IL-10) |
|---|
| Research Abstract |
To develop the diagnostic method for the prognosis of autoimmune disease, we investigated various immunoregulatory cells and molecules which may determine the pathogenesis and the prognosis of autoimmune disease, and clarified as follows.
1.In autoimmune thyroid disease, the proportions of regulatory CD25+CD4+ cells and NKT cells were lower in thyroid than in blood, and there was a possibility that FasL+CD4+CD8+ dendritic cells may cause apoptosis of Fas+CD4+ cells in thyroid.
2.Activated cytotoxic T cells and thyroid autoantibodies were independently involved in the development of hypothyroidism in Hashimoto's disease and a decrease of CD30 expression on CD30+CD8+ cells was also involved in this development.
3.The number of IgG3-secreting cells and the level of IL-10 were involved in the intractability of Graves' disease under treatment with anti-thyroid drugs.
4.Acquired activated protein C resistance was associated with anti-protein S antibody as a strong risk factor for deep vein thrombosis in non-SLE patients, and was associated with the co-existence of anti-prothrombin antibodies and lupus anticoagulant activity in SLE patients.
|
-
-
-
-
-
-
-
[Publications] Watanabe, M., Yamamoto, N., Maruoka, H., Tamai, H., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: "Independent involvement of CD8+CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease."Thyroid. 12. 801-88 (2002)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Nojima, J., Kuratsune, H., Suehisa, E., Kawasaki, T., Machii, T., Kitani, T., Iwatani, Y., Kanakura, Y.: "Acquired activated protein C resistance associated with anti-protein S antibody as a strong risk factor for DVT in non-SLE patients."Thromb. Haemost.. 88. 716-722 (2002)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Watanabe, M., Yamamoto, N., Maruoka, H., Matsuzuka, F., Miyauchi, A., Iwatani, Y.: "Relation of CD30 molecules on T-cell subsets to the severity of autoimmune thyroid disease."Thyroid. 13. 259-263 (2003)
Description
「研究成果報告書概要(欧文)」より
-
-
-
