2003 Fiscal Year Final Research Report Summary
Molecular-genetical approach to mutagenesis
| Project/Area Number |
14380251
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Kyoto University |
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Principal Investigator |
TODO Takeshi Kyoto University, Radiation Biology Center, Professor, 放射線生物研究センター, 教授 (90163948)
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| Project Period (FY) |
2002 – 2003
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| Keywords | UV-damage / Mutagenesis / TLS DNA polymerase / DNA damage |
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| Research Abstract |
Members of the Y-family of DNA polymerases catalyze template-dependent DNA synthesis but share no sequence homology with other known DNA polymerases. Y-family polymerases exhibits high error rates and low processivity when copying normal DNA but are able to synthesize DNA opposite damaged templates. We have found a novel regulatory pathway of Y-family polymerases. The Y-family polymerases are degraded by proteasome pathway in Drosophila cells when they are overexpressed. We have also identified the protein-protein interaction between Y-family polymerases. These findings will clarify the mutagenesis process in the evolutionary viewpoint.
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Research Products
(12 results)
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[Journal Article] Somatic mutation in larvae of the silkworm, Bombyx mori, induced by heavy ion irradiation to diapause eggs2002
Author(s)
E.Kotani, T.Furusawa, S.Nagaoka, K.Nojima, H.Fujii, Y.Sugimura, M.Ichida, E.Suzuki, A.Nagamatsu, T.Todo, M.Ikenaga
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Journal Title
J Radiat Res 43(3)
Pages: S193-8
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Somatic mutation in larvae of the silkworm, Bombyx mori, induced by heavy ion irradiation to diapause eggs2002
Author(s)
E.Kotani, T.Furusawa, S.Nagaoka, K.Nojima, H.Fujii, Y.Sugimura, M.Ichida, E.Suzuki, A.Nagamatsu, T.Todo, M.Ikenaga
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Journal Title
J Radiat Res 43 Suppl
Pages: S193-S198
Description
「研究成果報告書概要(欧文)」より
