2003 Fiscal Year Final Research Report Summary
Mechanisms of trhombocytopenia in dengue virus infections
| Project/Area Number |
14406019
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 海外学術 |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
OISHI Kazunori Nagasaki University, Institute of Tropical Medicine, Associate Professor, 熱帯医学研究所, 助教授 (80160414)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORITA Kouichi Nagasaki University, Institute of Tropical Medicine, Professor, 熱帯医学研究所, 教授 (40182240)
HASEBE Futoshi Nagasaki University, Institute of Tropical Medicine, Lecturer, 熱帯医学研究所, 講師 (20253693)
KUMATORI Atsushi Nagasaki University, Institute of Tropical Medicine, Lecturer, 熱帯医学研究所, 講師 (60244092)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | dengue virus / secondary infection / thrombocytopenia / PAIgG / PAIgM / severity of disease |
|---|
| Research Abstract |
Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue virus infection, the relationship between the PAIgG or PAIgM levels and disease severity as well as thrombocytopenia was examined in 78 patients with acute phase of secondary infection in a prospective hospital-based study. The decrease in platelet count during the acute phase significantly creased during the convalescent phase. In contrast, the increased levels of PAIgG or PAIgM that occured during the acute phase of these patients significantly decreased during the convalescent phase. An inverse correlation between platelet count and PAIgG or PAIgM levels was found in these patients. Anti-dengue virus IgG and IgM activity was found in platelet eluates from 10 patients in an acute phase of secondary infection. Increased levels of PAIgG or PAIgM were significantly higher in DHF than those in DF. An increased level of PAIgM was independently associated with the development of DHF, representing a possible predictor of DHF with a high specificity. Our present data suggest that platelet-associated immunoglobulins involving anti-dengue virus activity play an important role in the induction of thrombocytopenia and the severity of the disease in secondary dengue virus infections.
|
-
-
-
-
-
-
[Publications] Oishi K, Inoue S, Cinco MT, Dimaano EM, Alera MT, Alfon JA, Abanes F, Cruz DJ, Matias RR, Matsuura H, Hasebe F, Tanimura S, K matori A, Morita K, Natividad FF, Nagatake T: "Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections."J Med Virol.. 71. 259-264 (2003)
Description
「研究成果報告書概要(欧文)」より
-
-
[Publications] Cinco MTDD, Carlos CC, Oishi K, Inoue S, Matias RR, Cruz DJ, Hasebe F, Morita K, Natividad FF, Aguila FS, Igarashi A, Nagatake T: "The clinical, serological, and virological aspects of dengue fever/ demgue hemorrhagic fever in a private tertiary care hospital in Manila, Pilippines."St. Luke's J of Med.. 1. 9-12 (2003)
Description
「研究成果報告書概要(欧文)」より
-
-
[Publications] Takahashi H, Oishi K, Yoshimine H, Kumatori A, Moji K, Watanabe K, Nalwoga H, Tugume SB, Kebba A, Mugerwa R, Mugyenyi P, Nagatake T: "Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults."Clin Infect Dis.. 37. 1534-1540 (2003)
Description
「研究成果報告書概要(欧文)」より
