2004 Fiscal Year Final Research Report Summary
Clinical and molecular analysis of childhood cancer after Chernobyl
| Project/Area Number |
14406022
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
KOIKE Kenichi Shinshu University, Department of Pediatrics, School of Medicine, Professor, 医学部, 教授 (40143979)
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| Co-Investigator(Kenkyū-buntansha) |
AGEMATSU Kazunaga Shinshu University, Graduate School of Medicine, Institute of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Associate Professor, 大学院・医学研究科, 助教授 (60262721)
KAMIJO Takehiko Shinshu University, Department of Pediatrics, School of Medicine, 医学部附属病院, 講師 (90262708)
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| Project Period (FY) |
2002 – 2004
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| Keywords | Chernobyl accident / bone tumor / osteosarcoma / Ewing sarcoma / Belarus / Strontium 90 |
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| Research Abstract |
Of 23 radiation accidents that have occurred since 1945, the accident at the Chernobyl Nuclear Power Station in Ukraine, on 26 April 1986, has generated the largest number of victims. According to the International Atomic Agency, radioactive gases and aerosols released from the damage unit contaminated Belarus and Russia, as well as Ukraine. The Gomel, Mogilev and Brest region in Belarus received a high level of fallout containing ^<137>Cs. Most of the radionuclides are long-lived and have contaminated the inhabitants of this area. Radiation disasters induce various types of cancers with different latency periods ; these cancers include leukemia and thyroid and breast cancer. Kazarkov et al. reported a marked increase in the frequency of thyoid cancer in children in Belarus, in particular those in the Gomel region, 1990.
We performed a clinical survey to determine whether internal exposure to the long-lived radionuclide influenced the occurrence of childhood cancer, especially bone tumo
… More
r. In the present study, the clinical findings of children with neoplasms of bone were compared between the contaminated area (Gomel, Mogilev and Brest region) and non-contaminated area (Minsk, Grudno and Vitebsk) in Belarus. We also measured the content of ^<90>Sr in bone tumor. The frequency of patients with bone tumor has not increased after the accident. There were no differences in the ratio of male to female, types of bone tumor, involvement of contiguous organs and the percentages of metastasis between the patients living in contaminated areas and those in non-contaminated areas. It is of interest that the incidence of the patients at the age of younger than 10 years was significantly greater in contaminated areas than in non-contaminated areas (33.3% vs. 21.3%, p=0.0377). Additionally, 5 in 11 patients examined had higher levels of ^<90>Sr in bone tumors. Our previous study revealed that Gomel region had a higher percentage of patients with acute lymphoblastic leukemia at the age of two or lower than did the Vitebsk region. The frequent occurrence of childhood cancer at a young age observed in the area heavily contaminated with ^<137>Cs in Belarus may relate to the long exposure to the radioactives from the fetal period. Less
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[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
Author(s)
Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
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Journal Title
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.
Author(s)
Hasegawa D, Manabe A, Kubota T, Kawasaki H, Hirose I, Ohtsuka Y, Tsuruta T, Ebihara Y, Goto Y, Zhao XY, Sakashita K, Koike K, Isomura M, Kojima S, Hoshika A, Tsuji K, Nakahata T
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Journal Title
Description
「研究成果報告書概要(欧文)」より
