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2004 Fiscal Year Final Research Report Summary

Molecular analysis of G6PD variants in Asian Countries

Research Project

Project/Area Number 14406026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hematology
Research InstitutionJICHI MEDICAL SCHOOL

Principal Investigator

MATSUOKA Hiroyuki  Jichi Medical School, Departmentc Medical Zoology, Associate Professor, 医学部, 助教授 (10173816)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Shigeto  Jichi Medical School, Department of Medical Zoology, Lecturer, 医学部, 講師 (10296121)
ARAI Meiji  Jichi Medical School, Department of Medical Zoology, Lecturer, 医学部, 講師 (30294432)
HIRAI Makoto  Jichi Medical School, Department of Medical Zoology, Assistant Professor, 医学部, 助手 (50326849)
KAWAMOTO Fumihiko  Oita University, Facauty of Medicine, Institute of Scientific Research, Professor, 医学部, 教授 (40115556)
Project Period (FY) 2002 – 2004
KeywordsG6PD / malaria / molecular epidemiology / human genetics / metabolic abnormality / primaquine / anemia / Asia
Research Abstract

We conducted surveies of malaria diagnoses and glucose-6-phosphate dehydrogenase (G6PD) testing in remote areas of Asian countries. We took two drops of blood from the candidates by the finger prick method. One drop of blood was used for malaria diagnosis of Acridine orange method, and another drop of blood was for G6PD test using WST-8. Both diagnoses were completed within 30 minutes. Patients could receive anti-malarial medicine including primaquine when they had malaria parasites and their (G6PD conditions were normal. We obtained a small amount of blood from G6PD deficient subjects as well as informed consents, and analyzed DNA sequenses of G6PD gene. In Myanmar, more than 90% of G6PD deficient subjects showed G6PD Mahidol type (487G>A). However in Cambodia, more than 90% of G6PD deficient subjects showed G6PD Viangchan type (871G>A). These results indicate that both Myanmar people and Cambodian people are independently derived from homogeneous ancestries and different each other in terms of G6PD variant

  • Research Products

    (12 results)

All 2004 2003

All Journal Article (12 results)

  • [Journal Article] G6PD mutations in Myanmar. G6PD Mahidol (487G>A) is the most common variant in the Myanmar population2004

    • Author(s)
      Matsuoka H. et al.
    • Journal Title

      Journal of Human Genetics 49

      Pages: 544-547

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Rapid epidemiologic assessment of glucose-6-phosphate dehydrogenase deficiency in malaria-endemic areas in Southeast Asia using a novel diagnostic kit.2004

    • Author(s)
      Jalloh A. et al.
    • Journal Title

      Tropical Medicine and International Health. 9

      Pages: 615-623

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Laboratory evaluation of the ICT Malaria P.f./P.v. immunochromatographic test for detecting the panmalarial antigen using a rodent malaria model2004

    • Author(s)
      Arai M.et al.
    • Journal Title

      American Journal of Tropical Medicine and Hygeine 70

      Pages: 139-143

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Rapid epidemiologic assessment of glucose-6-phosphate dehydrogenase deficiency in malaria-endemic areas in Southeast Asia using a novel diagnostic kit.2004

    • Author(s)
      Jalloh A, Tantular IS, Pusarawati S, Kawilarang A P, Kerong H, Lin K, Ferreira M U, Matsuoka H, Arai M, Kita K, Kawamoto F.
    • Journal Title

      Trop Med Int Health 9(5)

      Pages: 615-623

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Laboratory evaluation of the ICT Malaria P.f./P.v. immunochromatographic test for detecting the panmalarial antigen using a rodent malaria model.2004

    • Author(s)
      Arai M, Ishii A, Matsuoka H.
    • Journal Title

      Am J Trop Med Hyg 70(2)

      Pages: 139-143

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar : G6PD Mahidol (487G>A) is the most common variant in the Myanmar population.2004

    • Author(s)
      Matsuoka H, Wang J, Hirai M, Arai M, Yoshida S, Kobayashi T, Jalloh A, Lin K, Kawamoto F.
    • Journal Title

      J Hum Genet 49(10)

      Pages: 544-547

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Five different G6PD variants found among 11 G6PD-deficient persons in Flores Island, Indonesia2003

    • Author(s)
      Matsuoka H. et al.
    • Journal Title

      Journal of Human Genetics 48

      Pages: 541-544

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An improved, simple screening method for detection of G6PD deficiency.2003

    • Author(s)
      Tantular IS et al.
    • Journal Title

      Tropical Medicine and International Health 8

      Pages: 569-574

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Two cases of G6PD deficient Nepalese belonging to the G6PD Mediterranean-type, not India-Pakistan sub-type but Mediterranean-Middle East sub-type2003

    • Author(s)
      Matsuoka H. et al.
    • Journal Title

      Journal of Human Genetics 48

      Pages: 275-277

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia.2003

    • Author(s)
      Matsuoka H, Arai M, Yoshida S, Tantular IS, Pusarawati S, Kerong H, Kawamoto F.
    • Journal Title

      J Hum Genet 48(10)

      Pages: 541-544

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] An improved, simple screening method for detection of glucose-6-phosphate dehydrogenase deficiency.2003

    • Author(s)
      Tantular IS, Kawamoto F
    • Journal Title

      Trop Med Int Health 8(6)

      Pages: 569-574

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Two cases of glucose-6-phophate dehydrogenase deficient Nepalese belonging to the G6PD Mediterranean-type, not India-Pakistan sub-type but Mediterranean-Middle East sub-type.2003

    • Author(s)
      Matsuoka H, Jichun W, Hirai M, Yoshida S, Arai M, Ishii A, Baral MP.
    • Journal Title

      J Hum Genet 48(5)

      Pages: 275-277

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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