2003 Fiscal Year Final Research Report Summary
Detection of parkinsonism causing substances in French West Indies
| Project/Area Number |
14406032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | HIROSHIMA UNIVERSIlY |
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Principal Investigator |
OHTA Shigeru Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (60160503)
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| Co-Investigator(Kenkyū-buntansha) |
KUZUHARA Shigeki Mie University, School of Medicine, Professor, 医学部, 教授 (70111383)
KOTAKE Yaichiro Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 (20335649)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Parkinson's disease / tetrahvdroisogunoline / Annonaceae family / SH-SY5Y cells / progressive supranuclear palsy |
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| Research Abstract |
In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. In the present study, we detected benzylisoquinoline derivatives in the Annonaceae family. These compounds were toxic to SH-SY5Y cells and inhibited mitochondrial respiratory complex I.
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