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2004 Fiscal Year Final Research Report Summary

Evaluation of functional correlation between excitatory amino acids and PGE2 in AV3V mechanisms regulating ADH secretion

Research Project

Project/Area Number 14570055
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNiigata University

Principal Investigator

YAMAGUCHI Ken'ichi  Niigata University, Graduate School of Medical and Denial Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (50108023)

Project Period (FY) 2002 – 2004
KeywordsForebrain(AV3V) / NMDA receptor / metabotropic Glu receptor / ADH secretion / ADH secretion / Bleeding / Prostaglandin E2 / Nitric oxide(NO)
Research Abstract

(1)In conscious rats, administrations of a NMDA receptor agonist NMDA or a metabotropic Glu receptor agonist t-ACPD into the anteroventral third ventricle (AV3V) stimulated ADH secretion and increased arterial pressure(AP) and heart rate(HR) in a dose-related manner. Moreover, the applications of NMDA, but not t-ACPD raised plasma osmolalily, glucose and hematocrte. All the effects of NMDA or t-ACPD, excepting the tachycardiac actions, were blocked by pre-administering respective antagonists MK-801 or MCPG.
(2)AV3V applications of PGE2 produced facilitation of AVP release and elevations of AP and HR. Pre-applications of MK-801 or MCPG blocked the ADH-reteasing effect of PGE2, without affecting its cardiovascular actions. The pressor action of PGE2 was inhibited by a histamine H1 receptor antagonist pyrilamine that exerted no effect on the cardiovascular responses to PGE2. Cyclic AMP caused PGE2-like actions when applied to AVSV, whereas pre-administrations of an adenyl cyclase inhibitor … More SQ22536 affected none of the the effects of PGE2 administered to AV3V.
(3)Intravenous infusions of hypertonic saline raised plasma ADH and AP progressively with time. The ADH response was selectively prevented by AV3V administrations of MK-801, whereas those of MCPG were without effect.
(4)Hypertensive bleeding, but not normotensive one, provoked by withdrawing arterial blood augmented plasma ADH, angiotensin II, osmolality and glucose. AV3V applications of MK-801 prevented the response of plasma ADH selectively, without changing those of the other variables. Such attenuation in the hemorrhagic ADH response was not produced by intraventricular applications of MK-801 or AV3V sdministrations of MCPG.
(5)Applications of a nitric oxide (NO)-releasing agent nitroprusside(NP) to AV3V facilitated ADH secretion, whereas the phenomenon was not evoked by the treatment with cGMP, a substance of which formation can be enhanced by NO. The NP-induced ADH response was not prevented, but intensified by pre-administrations of a guanyl cyclase inhibitor methylene blue, and abolished by those of a NO-scavenger hemoglobin.
(6)PGE2 levels in the interstitial fluid collected from AV3V area using a microdyalysis technique did not change significantly during intravenous infusions of hypertonic saline or after normotensive or hypotensive bleedings. Less

  • Research Products

    (18 results)

All 2004 2003 2002

All Journal Article (18 results)

  • [Journal Article] Pursuit of roles for metabotropic glutamate receptors in the anteroventral third ventricular region in regulating vasopressin secretion and cardiovascular function to conscious rats.2004

    • Author(s)
      Ken'ichi Yamaguchi
    • Journal Title

      Brain Research Bulletin 63(4)

      Pages: 321-329

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparative effects of quinapril with enalapril in rats with heart failure.2004

    • Author(s)
      Kenichi Watanabe
    • Journal Title

      Pharmacology 71

      Pages: 157-161

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Involvement of forebrain NMDA receptors in the hemorrhage-evoked vasopressin secretion.2004

    • Author(s)
      Ken'ichi Yamaguchi
    • Journal Title

      Japanese Journal of Physiology 54 Suppl.

      Pages: s219-s219

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pursuit of roles for metabotropic glutamate receptors in the anteroventral third ventricular region in regulating vasopressin secretion and cardiovascular function in conscious rats.2004

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe
    • Journal Title

      Brain Research Bulletin 63(4)

      Pages: 321-329

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparative effects of quinapril with enalapril in rats with heart failure.2004

    • Author(s)
      Kenichi Watanabe, Meilei Ma, Juan Wen, Hitoshi Tachikawa, Makoto Kodama, Yoshifusa Aizawa, Ken'ichi Yamaguchi, Toshihiro Takahashi
    • Journal Title

      Pharmacology 71

      Pages: 157-161

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of forebrain NMDA receptors in the hemorrhage-evoked vasopressin secretion.2004

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe
    • Journal Title

      Japanese Journal of Physiology 54 Suppl.

      Pages: s219

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Regulation of vasopressin secretion and cardiovascular function by metabotropic glutamate receptors distributed in the anteroventral third ventricle.2004

    • Author(s)
      Ken'ichi Yamaguchi, Hitoshi Hama, Mamoru Koike, Kanemitsu Yamaya
    • Journal Title

      Folia Endocrinologica Japonica 80(2)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A study on mechanism by which sodium nitroprusside, a nitric oxide donor, applied to the anteroventral third ventricular region provokes facilitation of vasopressin secretion2003

    • Author(s)
      Ken'ichi Yamaguchi
    • Journal Title

      Brain Research 968

      Pages: 35-43

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] NMDA receptors in the AV3V may mediate osmotic AVP secretion without depending on enhanced production of nitric oxide.2003

    • Author(s)
      Ken'ichi Yamaguchi
    • Journal Title

      Proceedings of the 2003 World Congress On Neurohypophysial Hormones

      Pages: 94-94

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A study on the mechanism by which sodium nitroprusside, a nitric oxide donor, applied to the anteroventral third ventricular region provokes facilitation of vasopressin secretion in conscious rats.2003

    • Author(s)
      Ken'ichi Yamaguchi, Hitoshi Hama
    • Journal Title

      Brain Research 968

      Pages: 35-43

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Involvement of AV3V NMDA receptors in the osmotic and volemic ADH secretion.2003

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe
    • Journal Title

      Japanese Journal of Physiology 53 Suppl.

      Pages: s291

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] NMDA receptors in the AV3V may mediate osmotic AVP secretion without depending on enhanced production of nitric oxide.2003

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe, Hitoshi Hama, Kanemitsu Yamaya
    • Journal Title

      Proceedings 2003 World Congress Neurohypophysial Hormones 94

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cerebral areas and bioactive substances involved in hyperosmolality-evoked AVP secretion.2003

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe, Hitoshi Hama, Kanemitsu Yamaya
    • Journal Title

      Proceedings 2003 World Congress Neurohypophysial Hormones 95

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Control of vasopressin release and cardiovascular system by AV3V glutamate receptors.2003

    • Author(s)
      Ken'ichi Yamaguchi, Hitoshi Hama, Kanemitsu Yamaya
    • Journal Title

      Folia Endocrinologica Japonica 78(1)

      Pages: 141

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Vasopressin secretion stimulated by forebrain nitric oxide and involved mechanisms.2003

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe, Hitoshi Hama, Kanemitsu Yamaya
    • Journal Title

      Folia Endocrinologica Japonica 79(2)

      Pages: 367

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Contribution of N-methyl-D-aspartate receptors in the anteroventral third ventricular region to vasopressin secretion, but not to cardiovascular responses provoked by hyperosmolality and prostaglandin E2 in conscious rats.2002

    • Author(s)
      Ken'ichi Yamaguchi
    • Journal Title

      Brain Research Bulletin 58(3)

      Pages: 301-309

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Contribution of N-methyl-D-aspartate receptors in the anteroventral third ventricular region to vasopressin secretion, but not to cardiovascular responses provoked by hyperosmolality and prostaglandin E2 in conscious rats.2002

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe
    • Journal Title

      Brain Research Bulletin 58(3)

      Pages: 301-309

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Regulation of ADH secretion by excitatory amino acid receptors in the AV3V.2002

    • Author(s)
      Ken'ichi Yamaguchi, Kazuo Watanabe
    • Journal Title

      Japanese Journal of Physiology 52 Suppl.

      Pages: s194

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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