2003 Fiscal Year Final Research Report Summary
Induction Mechanisms of Memory T Cells
| Project/Area Number |
14570276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Chiba University |
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Principal Investigator |
TOKUHISA Takeshi Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (20134364)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Akemi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (90359597)
ARIMA Masafumi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (00202763)
HATANO Masahiko Chiba University, Gene Research Center, Associate Professor, 遺伝子実験施設, 助教授 (20208523)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Memory T cells / Transcription factor / BCL6 / Transgenic mice / Homeostatic proliferation / Central memory T cells / BAZF / CD8 T cells |
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| Research Abstract |
Naive T cells proliferate and differentiate into memory cells after antigenic stimulation or in a lymphopenic environment. We showed here transient increases in memory phenotype CD8^+ T cell numbers in the lymphopenic environment of spleens of very young mice. The magnitude of the increase correlated with Bcl-6 expression in the T cells. Bcl-6 controlled the generation and maintenance of antigen-specific memory phenotype CD8^+ T cells in the spleens of immunized mice. These data suggest that Bcl-6, which is also essential for memory B cell development in germinal centers, is a key molecule for the establishment not only of memory T cells but also of the peripheral T cell compartment in infancy.
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