2003 Fiscal Year Final Research Report Summary
Relationship between Stomach Cancer and Helicobacter pylori Infection, Growth Factors and Cytokines among Young Adults
| Project/Area Number |
14570363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Aichi Medical University |
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Principal Investigator |
KIKUCHI Shogo Aichi Medical University, School of Medicine, Professor, 医学部, 教授 (40224901)
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| Co-Investigator(Kenkyū-buntansha) |
YAGYU Kiyoko Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (50268017)
YINGSONG Lin Aichi Medical University, School of Medicine, Lecturer, 医学部, 講師 (50340302)
OBATA Yuki Aichi Medical University, School of Medicine, Research Associate, 医学部, 助手 (70340304)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Stomach cancer among young adults / Case-control study / Cu, Zn-superoxide dismutase / Epidermal growth factor / Epidermal growth factor receptor / Interleukine-6 / Soluble Fas / Helicobacter pylori |
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| Research Abstract |
Using plasma of 55 stomach cancer patients under 40 years of age and their age and gender matched 55 screenees, pepsinogen (PG), H. pylori antibody, inteleukine-8 (IL-8), Cu, Zn-superoxide dismutase (Cu, Zn-SOD), inteleukine-6 (IL-6), epidermal growth factor (EGF), its receptor (EGF-R), transforming growth factor β-1 (TGF β-1), soluble Fas (sFas) and midkine were measured.
High PG1 and PG2 concentrations and low PG1/PG2 ratio were positive related with risk for stomach cancer. The optimal sensitivity and specificity were 83.3% and 81.5%. Cu, Zn-SOD, EGF, EGF-R, TGF β-1, and sFas showed negative association with the risk, but the significant association of TGF β-1, and sFas disappeared when adjusted for H. pylori status. The negative association of EGF and EGF-R can be explained by feedback down-regulation or increased consume of the factors. The disappearance of significance regarding TGF β-1, and sFas by adjustment for H. pylori status seems to indicate that relationship between these factors and risk for stomach cancer is related with H pylori infection.
IL-6 showed positive association with risk for stomach cancer, but significance disappeared with adjustment for H pylon status. From the results it may be hypothesized that H pylori infection elevated and the elevated IL-6 increased risk for stomach cancer. However, further investigation is necessary to confirm the hypothesis.
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