2003 Fiscal Year Final Research Report Summary
A retrospective cohort study for investigating a high risk association of serum lipid, gluclose tolerace to cancer incidence among A-bomb survivors
| Project/Area Number |
14570377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
SUYAMA Akihiko Radiation Effects Research Foundation, Epidemiology Department, Chief (Researcher), 疫学部, 部長(研究員) (10144651)
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| Co-Investigator(Kenkyū-buntansha) |
SODA Midori Radiation Effects Research Foundation, Epidemiology Assistant Department, Chief (Researcher), 疫学部, 副部長(研究員) (00359457)
AKAHOSHI Masazumi Radiation Effects Research Foundation, Epidemiology Assistant Department, Chief (Researcher), 臨床研究部, 部長(研究員) (30359450)
KONDO Hisayoshi Nagasaki University, School of Medicine, Assistant, 医学部, 助手 (00170431)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Glucose Metabolism / Lipid Metabolism / Cancer Incidence / Radiation Exposure |
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| Research Abstract |
The relationship between lipid or glucose metabolism and cancer has not yet been elucidated. We conducted 75g oral glucose tolerance tests (75g OGTT) and lipid measurements between 1983 and 1985 in 516 Nagasaki atomic bomb survivors. Excluding those who already had cancer at the baseline examinations and those who developed cancers or died of any cause within five years after the baseline examinations, we determined incident cancer cases until 2000 in the remaining 451 subjects (214 males and 237 females) and evaluated whether glucose or lipid metabolism predicts cancer development by means of Cox proportional hazard model.
The age- and sex-adjusted relative risk (RR) for incident cancer was 0.903 (95% confidence interval (95%CI), 0.842-0.968), 1.740 (95% CI, 1.238-2.446), 1.653 (95% CI, 0.922-2.965) and 1.024 (95% CI, 0.996-1.053) for total cholesterol (10mg/dl), radiation dose (1Sv, smoking and 1-hour blood glucose (1h BG; 10mg/dl) in 75g OGTT, respectively. Multiple regression analysis of age, sex, smoking, body mass index, lh BG, triglycerides, total cholesterol, HDL cholesterol, and radiation dose also showed that total cholesterol was negatively (RR, 0.876; 95% CI, 0.791-0.957) and radiation dose positively (RR, 1.809; 95% CI, 1.252-2.613) related to incident cancer.
Cholesterol could be negatively and radiation dose positively associated with cancer development independently.
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Research Products
(10 results)
