2005 Fiscal Year Final Research Report Summary
Analysis of Prostanoid receptor subtypes in interstitial pneumonitis
| Project/Area Number |
14570427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | Kitasato University |
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Principal Investigator |
ENDO Hirahito Kitasato University, School of Medicine, Associate professor, 医学部, 助教授 (20213598)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Sumiaki Kitasato University, School of Medicine, Assistant professor, 医学部, 講師 (80265595)
YOSHIDA Hide Kitasato university, School of Medicine, Research Associate, 医学部, 助手 (60327377)
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| Project Period (FY) |
2002 – 2005
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| Keywords | interstitial pneumonitis / bleomycin / 15 deoxy-prostaglandin J2 / Lipoxin / Thromboxane / Scleroderma / Leukotriene |
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| Research Abstract |
1.15 deoxy-prostaglandin J2 (15d-PGJ2) suppress mouse interstitial pneumonitis induced bleomycin. 15d-PGJ2 is a legand of nuclear receptor, peroxysome-proliferator activated receptor gamma. PPAR gamma highly expressed in lung lesion of bleomycin-induced interstitial pneumonitis
15d-PGJ2 is a stable metabolite of PGD2. PGD syntase retrovirally transfected fibroblasts also inhibited interstitial pneumonitis.
2.15d-PGJ2 inhibited skin sclerosis and lung fibrosis in bleomycin-induced mouse scleroderma model. In this disease model mast cells highly infiltrated in skin and lung and plasma histamine levels increased in this model. 15-dPGJ2 inhibited mast cell activation, histamine release.
3.Lipoxin A4 receptor (ALX) increased bleomycin-induced interstitial pneumonitis. Lipoxin A4 inhibited TGF beta induced lung fibroblast proliferation and collagen synthesis. And TXA2 receptor also induced in induced. ALX induced by TX syntase inhibitor.
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[Journal Article] Inhibition of skin sclerosis by 15deoxy Delta(12,14)-prostaglandin J(2) and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma.2006
Author(s)
Kohno, S., Endo, H., Hayashi, I., Murakami, Y., Kitasato, H., Kawai, S., Kondo, H
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Journal Title
Biomed Pharmacotherapy, 60
Pages: 18-25
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Induction of Triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals,2006
Author(s)
Murakami, Y, Akahoshi, T, Hayashi, I, Endo, H, Kondo, H, Kawai, S, Inoue M, Kitasato H
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Journal Title
Arthritis Rheum, 54
Pages: 455-462
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Regulatory expression of lipoxin A4 receptor inphysiologically estrus cycle and pathologicallyendometriosis.2005
Author(s)
Motohashi, E., Kawauchi, H, Endo, H, Kondo H, Kitasato, H., Kuramoto, H., Majoma, M., Ueno, N., Hayashi, I.
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Journal Title
Biomed Pharmacotherapy, 59
Pages: 330-338
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Host Stromal Bradykinin B2 receptor Signaling facilitates Tumor- Associated angiogenesis and Tumor growth.2004
Author(s)
Ikeda.Y.Hayashi, I, Kamoshita, E, Yamazaki, Endo, H.Ishihara, K., Yamashina, S.Tsutsumi, Y., Matsubara, H.Majima
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Journal Title
Cancer Res 64(15)
Pages: 5178-5185
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.2003
Author(s)
Ando M, Murakami Y, Kojima F, Endo H, Kitasato H, Hashimoto A, Kobayashi H, Majima M, Inoue M, Kondo H, Kawai S, Hayashi I.
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Journal Title
Am J Respir Cell Mol Biol. 28(5)
Pages: 582-591
Description
「研究成果報告書概要(欧文)」より
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