2003 Fiscal Year Final Research Report Summary
Establishment of diagnostic procedures for paraneoplastic neurological syndrome with specific-antineuronal antibodies, and the study for the pathomechanisms of paraneoplastic neurological syndrome
| Project/Area Number |
14570583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
TANAKA Keiko NIIGATA UNIVERSITY, Brain Research Institute, Associate Professor, 脳研究所, 助教授 (30217020)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Shoji the University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70150612)
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| Project Period (FY) |
2002 – 2003
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| Keywords | paraneopolastlc neurological syndrome / anti-neuronal antibody / recombinant antigen protein |
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| Research Abstract |
For the specific and quick diagnosis of paraneoplastic neurological syndromes, we produced several recombinant antigen proteins (Yo/Hu/Ri/CRMP-5,/Ma-2) and used as antigens for western blot or ELISA. We analysed the frequency of these antibody positivity among 1500 samples which sent us for the diagnosis of paraneoplastic neurological syndromes. We found anti-Yo antibody in 1.5% of these sera and anti-Hu antibody in 2.3%.
For those with specific antibody-positive patients, we analysed the HLA type under the informed consent, and found the similar amimo acid motifs in their class I molecules, which would be used as the targets for cytotoxic T cell assay.
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[Publications] Arai A, Tanaka K, Ikeuchi T, Igarashi S, Kobayashi H, Asaka T, Date H, Saito M, Tanaka H, Kawasaki S, Uyama E, Mizusawa H, Fukiihara N, Tsuji S.: "A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees with DMRV (Nonaka myopathy)."Ann Neurlo. 52. 516-519 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ishihara N, Yamada K, Yamada Y, Miura K, Kato J, Kuwabara N, Hara Y, Kobayashi Y, Hoshino K, Nomura Y, Mimaki M, Ohya K, Matsushima, M, Niita H, Tanaka K, Segawa M, Ohki T, Ezoe T, Kumagai T, Onuma A, Kurada T, Yoneda M, Yamanaka T, saeki M, Segawa M, Saji T, Nagaya M, Wakamatsu N.: "Clinical and molecular analysis of Mowat-Wilson syndrome associated with ZFHX1B mutations and deletions at 2q22-q24.1"J Med Genet. 41. 387-393 (2004)
Description
「研究成果報告書概要(欧文)」より
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