2003 Fiscal Year Final Research Report Summary
C-type Natriuretic Peptide Prevents Cardiac Remodeling after Myocardial Infarction.
| Project/Area Number |
14570710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KISHIMOTO Ichiro National Cardiovascular Center Research Institute, Head of Biochemistry, 生化学部, 室長 (80312221)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Yoshihiro Kyoto University, Department of Medicine and Clinical Science, Assistant Professor, 医学部・研究科, 助手 (70291424)
SAITO Yosihiko Nara Medical University, First Department of Internal Medicine, Professor, 第1内科学教室, 教授 (30250260)
KANAGAWA Kenji National Cardiovascular Center Research Institute, Director of Biochemistry, 生化学部, 部長 (00112417)
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| Project Period (FY) |
2002 – 2003
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| Keywords | myocardial infarction / natriuretic peptides / remodeling / fibrosis / angiogenesis / hypertrophy |
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| Research Abstract |
We assessed the hypothesis that the in vivo administration of C-type natriuretic peptide (CNP) might attenuate cardiac late remodeling after myocardial infarction (MI). When CNP was intravenously infused for 2 weeks in rats with MI, the left ventricular enlargement and dysfunction caused by MI were improved by CNP. CNP significantly attenuated an increase in morphometrical collagen volume fraction in the non-infarct region and improved capillary density. The increases of collagen I, collagen III, atrial natriuretic peptide, and β-myosin heavy chain mRNA levels in the non-infarct region were also suppressed by CNP. In conclusion, CNP might be useful as a novel cardioprotective agent.
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[Publications] Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Takahashi N, Kawakami R, Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K: "Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart."Circulation. 106. 1722-8 (2002)
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「研究成果報告書概要(欧文)」より
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[Publications] Adachi Y, Saito Y, Kishimoto, I, Harada M, Kuwahara K, Takahashi N, Kawakami R, Nakanishi M, Nakagawa Y, Tanimoto K, Saitoh Y, Yasuno S, Usami S, Iwai M, Horiuchi M, Nakao K.: "Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice."Circulation. 107. 2406-8 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K.: "NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function."EMBO J.. 22. 6310-21 (2003)
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「研究成果報告書概要(欧文)」より
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[Publications] Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Hamanaka I, Takahashi N, Kawakami R, Tanimoto K, Nakagawa Y, Nakanishi N, Kawakami R, Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K.: "Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A."Endocrinology. 145. 951-8 (2003)
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「研究成果報告書概要(欧文)」より
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