2003 Fiscal Year Final Research Report Summary
Normal database of cerebral blood flow and cerebral oxygen metabolism measured with PET and O-15 labeled gas.
| Project/Area Number |
14570900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Institute of Biomedical Research and Innovation |
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Principal Investigator |
SENDA Michio Institute of Biomedical Research and Innovation, Department of Image-based medicine, Director, 映像医療研究部, 部長 (00216558)
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| Co-Investigator(Kenkyū-buntansha) |
CHEN Guoyue Akita Prefectural University, Faculty of System Science and Technology, Associate Profesor, システム科学技術学部, 助教授 (20282014)
ITO Hiroshi Tohoku University, Tohoku University Hospital, Lecturer, 医学部付属病院, 講師 (20360357)
SAKAMOTO Setsu Institute of Biomedical Research and Innovation, Senior Research Scientist, 映像医療研究部, 主任研究員 (40344402)
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| Project Period (FY) |
2002 – 2003
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| Keywords | PET / O-15 labeled gas / regional cerebral blood flow / regional cerebral oxygen metabolism / regional cerebral oxygen extraction fraction / multicenter study / normal database |
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| Research Abstract |
Measurement of CBF, cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF), and CMRO_2 by positron emission tomography (PET) with ^<15>O-labeled carbon dioxide (C^<15>O_2) or ^<15>O-labeled water 8H_2^<15>O), ^15O-labeled carbon monoxide (C^<15>O), or ^<15>O-labeled oxygen (^<15>O_2) is useful for diagnosis and treatment planning in cases of cerebrovascular disease. The measured values theoretically depend on factors that differ between PET centers. PET data of 70 healthy volunteers from 11 PET centers were analyzed. Steady-state method was used in 7 centers for C^<15>O_2 and in 8 centers for ^<15>O_2. Non-steady-state method was used in the other centers. The partition coefficient of water varied from 0.8 to 1.0 depending on the centers. Overall mean ± SD values for cerebral cortical regions were : CBF = 44.4 ± 6.5 mL/100 mL/min ; CBV = 3.8 ± 0.7 mL/100 mL ; OEF = 0.44 ± 0.06 ; CMRO_2 = 3.3 ± 0.5 mL/100 mL/min ; the variations being acceptable small, suggesting the practicability of building a normal database for ^<15>O-labeled gas sturdy. The CBF image of each subject was further spatially normalized into the standard Talairach coordinates system using SPM99, and the other three parametric images were transformed with the same transformation. This procedure created the average normal images of each parameter in the standard coordinates system, which may provide normal values for each brain region in the image format.
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