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2003 Fiscal Year Final Research Report Summary

Neuropathological studies on the vulnerability to mood disorders and refractoriness to antidepressant treatment.

Research Project

Project/Area Number 14570909
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

MIKUNI Masahiko  Gunma University, Neuropsychiatry, Professor, 医学部, 教授 (00125353)

Co-Investigator(Kenkyū-buntansha) MAJIMA Takehiko  Gunma University, Neuropsychiatry, Assistant, 医学部, 助手 (00312869)
IDA Itsuro  Gunma University, Neuropsychiatry, Instructor, 医学部, 講師 (50251103)
FUKUDA Masato  Gunma University, Neuropsychiatry, Associate Professor, 医学部, 助教授 (20221533)
Project Period (FY) 2002 – 2003
Keywordsmood disorder / 18F-FDG-PET / DEX / CRH test / pre-frontal cortex / superior temporal gyrus / para-hippocampal gyrus / vulnerability / postmortem brain
Research Abstract

To clarify a neuronal vulnerability in primary mood disorder, we have investigated if cytoarchitectural alterations would be observed in the left prefrontal cortex, BA 9 in postmortem brain tissue from subjects with primary mood disorder, who were under long-term treatment with antidepressant and mood stabilizers. The left prefrontal cortex, BA 9 is documented to be one of the pathophysiological brain regions, and we have clearly demonstrated that the lowered glucose uptake activity was estimated by FDG-PET, in the left prefrontal cortex, BA 9, in depressive state-depended manner. Reduction in the density of small cell neurons has been observed in layer II, but not in I, III, IV in the left BA 9. There are no changes in glial density and large neuronal cell density in the left BA 9, although the decrease was observed through the depth of cortex of BA 9, compared with normal controls. Interestingly, the number of serotonin (5-HT)-2A receptor immunorecative cells was significantly increased in layer II, but not in I, III, IV in the left BA 9 in postmortem brain from subjects with primary mood disorder. The density of 5-HT-2A receptor binding sites is well-known to be down-regulated after subchronic administration of antidepressant agents in rat cerebral cortex. Therefore, the layer II in the left prefrontal cortex, BA 9 is of special interest in the vulnerability in primary mood disorder and refractoriness to antidepressant treatment.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kameyama M, Fukuda M, Uehara T, Mikuni M: "Sex and age dependencies of cerebral blood volume changes during cognitive activation : A multichannel near-infrared spectroscopy study."NeuroImage. in press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suto T, Fukuda M, Ito M, Uehara T, Mikuni M: "Multichannel near-infrared spectroscopy in depression and schizophrenia : cognitive brain activity study."Biological Psychiatry. 55. 501-511 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuyama-Tamura M, Mikuni M, Kojima I: "Modulation of the glucocorticoid receptor function by antidepressant compounds."Neuroscience Letter. 342. 206-210 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nemoto H, Toda H, Nakajima T, Hosokawa S, Konno Y, Yamamoto K, Horiuchi R, Inoue T, Endo K, Ida I, Mikuni M, Matsubara K, Goto F: "Regional cerebral blood flow in human antinociception with fluvoxamine."Neuroreport. 14. 2003 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uehara T, Kazuo Takeuchi K, Ohmori I, Kawashima Y, Goto M, Mikuni M, Vandereycken W: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan : comparisons with the original Belgian study."Psychiatry Research. 111. 241-246 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三國 雅彦: "統合失調症治療ガイドライン 精神医学講座担当者会議監修 佐藤光源、井上新平編"医学書院. 180-186 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uehara T, Ohmori T, Goto M, Kawashima Y, Moro H, Fukuda M, Mikuni M: "Eating disorders and family functioning - Relationships with diagnostic classifications, symptoms, and outocomes. In : Focus on Eating Disorders Research, edited by Pamela I.Swain"Nova Biomedical Books, New York. 135-150 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Relationship between Vulnerability of Major Depressive Disorder and Prenatal Stress or Glucocorticoid Treatment. In : Recent Advances in the Research of Affective Disorder in Japan, ed.By Okuma T, Kanba S, Inoue Y"Elsevier Science. 43-49 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suto T, Fukuda M, Ito M, Uehara T, Mikuni M: "Multichannel near-infrared spectroscopy in depression and schizophrenia : cognitive brain activity study."Biological Psychiatry. 55. 501-511 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuyama-Tamura M, Mikuni M, Kojima I: "Modulation of the glucocorticoid receptor function by antidepressant compounds."Neuroscience Letter. 342. 206-210 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nemoto H, Toda H, Nakajima T, Hosokawa S, Konno Y, Yamamoto K, Horiuchi R, Inoue T, Endo K, Ida I, Mikuni M, Matsubara K, Goto F: "Regional cerebral blood flow in human antinociception with fluvoxamine."Neuroreport. 14. 791-797 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Relationship between Vulnerability of Major Depressive Disorder and Prenatal Stress or Glucocorticoid Treatment. In : Recent Advances in the Research of Affective Disorder in Japan, ed. By Okuma T, Kanba S, Inoue Y"Elsevier Science. 43-49 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uehara T, Kazuo Takeuchi K, Ohmori I, Kawashima Y, Goto M, Mikuni M, Vandereycken W: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan comparisons with the original Belgian study."Psychiatry Research. 111. 241-246 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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