NOMURA Kenji NAGOYA UNIVERSITY, UNIVERSITY HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (50345899)
MURASE Satomi NAGOYA UNIVERSITY, CENTER FOR DEVELOPMENTAL CLINICAL PSYCHOLOGY AND PSYCHIATRY, ASSOCIATE PROFESSOR, 発達心理精神科学教育研究センター, 助教授 (30335020)
HONJO Syuji NAGOYA UNIVERSITY, CENTER FOR DEVELOPMENTAL CLINICAL PSYCHOLOGY AND PSYCHIATRY, PROFESSOR, 発達心理精神科学教育研究センター, 教授 (90181544)
The reports on a linkage analysis of autism have been increasing in number in these years. Most of them found some linkage between autism and alleles/genes, while all of them failed in finding concrete promised genes/alleles. Among the candidate, chromosome 7 is the most promised. In 7p32, specially, is found imprinting gene which will be analyzed an association with autism.
The whole genome linkage studies of autism have been done by Schao et.al. (2002, 99family, 352allele), Alarcon et.al. (2002, 152family, 335allele), Auranen et.al. (2002, 38family, 369allele), Buxbaum et.al. (200 1, 95family, 382allele), IMGSAC(2001,152pair, 394allele), Liu et.al. (2001, 110family, 335allele), Risch et.al (1999, 139familiy, 519allele). Some other groups also reported the result of the linkage study by less alleles. While it is difficult to find a strong candidate allele/gene, there exist common results that some chromosomes may have a linkage with autism
Some groups are trying to extract a probable genetically homogeneous subgroup from their subjects. For example, Shao et.al. (2002) reported a linkage between 2q and the autism with speech-onset delay. They also used an Ordered-Subset Analysis and found a subgroup with strong sameness. Because autism is a behavioral syndrome and consists of genetically heterogeneous subgroups, a trial to find subgroups genetically homogeneous will be done in a several years from now on. In order to get a better result from linkage study, which of the family member should be included as an carrier with minor symptom must be considered.