2003 Fiscal Year Final Research Report Summary
The role of LOX-1 and oxidative stress in the progressive renal disease.
| Project/Area Number |
14571015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANAME Shinya The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (60224581)
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| Project Period (FY) |
2002 – 2003
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| Keywords | LOX-1 / oxidative stress |
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| Research Abstract |
In this study, we investigated the LOX-1 expression 1in chronic renal failure model rats. 6 weeks after 5/6 nephrectomy, renal LOX-1 mRNA expression was markedly increased compared with control, which accompanied by elevation of blood pressure and impaired renal function. Immunohistochemical analysis showed that LOX-1 was widely expressed in the interstitial cells, although there was almost no staining in the glomeruli and tubules. Moreover, AT1 antagonist candesartan significantly suppressed the renal LOX-1 expression. These results suggest that enhanced renal expression of LOX-1 might play a role in the progression of chronic renal failure in rats.
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