2003 Fiscal Year Final Research Report Summary
Effect of DHEA(S) on the progression of life style related disease : epidemiological and basic analysis.
| Project/Area Number |
14571061
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
YAMAMOTO Mayumi Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (40313879)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIZAWA Masayoshi Gifu University Hosp., 3rd Dept. of Int. Med., Lectureler, 医学部附属病院, 講師 (20313893)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | DHEA / insulin / insulin resisitance / PPAR / fat / breast cancer / obesity |
|---|
| Research Abstract |
We investigated effects of DHEA(S) on the progression of life style-related diseases.
DHEA and insulin resistance : DHEA activated P13-kinase and atypical PKC in rat adipocytes. Since these activation induced glucose uptake, DHEA may improve insurin resistance in the insulin target organs.
DHEA and obesity : DHEA decreased the expression levels of PPAR and triglyceride volume through the suppression of mRNA levels in adipocyte lipid-binding protein and sterol regulatory element-binding protein. DHEA might have an important roles in function of adipocytes.
DHEA and breast cancer : DHEA increased the human breast cancer cell proliferation as a mitogen, which was diminished with 4-hydroxyandrostendione inhibiting aromatase enzyme.
DHEA administration might have an advantage to prevent some of life style-related diseases like obesity and diabetes mellitus.
|
