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2004 Fiscal Year Final Research Report Summary

Study for pathophysiological significance of growth hormone in adult men.

Research Project

Project/Area Number 14571074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionTokyo Women's Medical University

Principal Investigator

TAKANO Kazue  Tokyo Women's Medical University, School of Medicine Department of Medicine II, Professor, 医学部, 教授 (50096608)

Co-Investigator(Kenkyū-buntansha) HIZUKA Naomi  Tokyo Women's Medical University, School of Medicine Department of Medicine II, Professor, 医学部, 教授 (80147397)
FUKUDA Izumi  Tokyo Women's Medical University, School of Medicine Department of Medicine II, Assistant Professor, 医学部, 講師 (80238477)
MURAKAMI Yuko  Tokyo Women's Medical University, School of Medicine Department of Medicine II, Clinical Associate, 医学部, 助手 (60318029)
Project Period (FY) 2002 – 2004
Keywordsgrowth hormone(GH) / Adult GH deficiency(GHD) / acromegaly / insulin resistance / adipocytokine / impaired glucose tolerance / impaired lipid metabolism
Research Abstract

In this study, we have investigated pathophysiological significance of growth hormone in adult men as follows.
1.Metabolic disorders in patients with adult growth hormone deficiency and acromegary.
Clinical and biochemical data of patients with adult GHD(AGHD) and acromegaky who attended Tokyo Women's Medical University were analyzed retrospectively from medical records.
In AGHD, diabetes mellitus and impaired glucose tolerance was found in 4 and 16% of the patients, respectively. Forty-two percent of the patients had hypercholesterolemia, 41% had hypertriglyceridemia, 55% had decreased levels of HDL cholesterol. Thirty-five % of the patients had body mass index(BMI) being>25 kg/m^2. Abnormal findings including increased Intima-media thickness(IMT) or plaque being observed in 27 and 20% of the patients. The homeostasis model insulin resistance index(HOMA-R) was 2.87±0.38, suggesting insulin resistance. These data suggest that abnormal lipid and glucose metabolism, and atherosclerotic chan … More ges occur frequently in adult patients with GHD. Insulin resistance may play a role in disorders of glucose and lipid metabolism associated with GHD.
In patients with acromegaly, diabetes mellitus and impaired glucose tolerance was found in 45 and 33% of the patients, respectively. Acromegalics had high HOMA-R (3.59±0.56). Serum GH levels in the patients with DM were higher than those in NGT, but, serum IGF-I levels and SDS were not different among the groups. These data suggests that IGF-I might not play the role of glucose metabolism in these patients.
2.Serum levels of adipocytokines in adult growth hormone deficiency and acromegaly
Atherosclerosis and insulin resistance are common complications of adult growth hormone deficiency(GHD) and acromegaly. Circulating adiponectin, an adipocyte-derived protein, has both anti-atherogenic and insulin-sensitising effects. The values of QUICKI as insulin sensitivity index were significantly lower in patients with acromegaly or adult GHD compared to normal subjects (0.33±0.03,0.35±0.04,and 0.36±0.01,respectively). While patients with adult GHD had significantly lower serum adiponectin levels than patients with acromegaly (6.5±3.9,9.2±5.0,P<0.01) these levels were not significantly different from those found in normal subjects (7.8±4.3 μg/ml). There was an inverse correlation between serum adiponectin levels and BMI in both patient groups. However, serum adiponectin levels correlated positively with QUICKI (Rs=0.37,) only in patients with adult GHD. These results demonstrate that adiponectin levels are significantly lower in patients with adult GHD than in patients with acromegaly. Adiponectin levels are similar in patients with GHD and healthy controls, whereas in patients with acromegaly, insulin resistance appears to be not closely related to adiponectin levels compared with BMI. The different relationship between adiponectin and QUICKI observed in the adult GHD and acromegaly groups presumably reflects differences in the mechanisms of insulin resistance under states of GH deficiency or excess.
Serum resistin levels were also investigated in patients with GHD and acromegaly. Less

  • Research Products

    (21 results)

All 2005 2004 2003 2002

All Journal Article (20 results) Book (1 results)

  • [Journal Article] Pediatric nonalcoholic steatohepatitis associated with hypopituitarism.2005

    • Author(s)
      Nakajima K, Hashimoto E, Kaneda H, Tokushige K, Shiratori K, Hizuka N, Takano K
    • Journal Title

      J Gastroenterol 40

      Pages: 312-315

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Serum adiponectin levels in adult growth hormone deficiency and acromegaly2004

    • Author(s)
      Fukuda I, et al.
    • Journal Title

      Growth Horm IGF Res 14

      Pages: 449-454

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 成長ホルモン(GH)の代謝作用-成人GH分泌低下症の臨床-2004

    • Author(s)
      高野加寿恵
    • Journal Title

      日本内科学会雑誌 93

      Pages: 2022-2027

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metabolic effects of 20-kilodalton human growth hormone (20K-hGH) for adults with growth hormone deficiency.2004

    • Author(s)
      Hayakawa M, et al.
    • Journal Title

      J Clin Endocrinol Metab 89

      Pages: 1562-1571

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 過去5年間に当科で診療した先端巨大症82例における治療成績と合併症2004

    • Author(s)
      福田いずみ 他
    • Journal Title

      日本内分泌学会誌 80(Suppl)

      Pages: 82-83

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metabolic effect of growth hormone. Clinical features of GH deficiency in adults.2004

    • Author(s)
      Takano K
    • Journal Title

      J Jap Soc Internal Med 93

      Pages: 2022-2027

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Serum adiponectin levels in adult growth hormone deficiency and acromegaly.2004

    • Author(s)
      Fukuda I, Hizuka N, Ishikawa Y, Itoh E, Yasumoto K, Murakami Y, Sata A, Tsukada J, Kurimoto M, Okubo Y, Takano K
    • Journal Title

      Growth Horm IGF Res 14

      Pages: 449-454

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa.2004

    • Author(s)
      Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N, Takano K
    • Journal Title

      J Clin Endocrinol Metab 89

      Pages: 5707-5712

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Metabolic effects of 20-kilodalton human growth hormone (20K-hGH) for adults with growth hormone deficiency : results of an exploratory uncontrolled multicenter clinical trial of 20K-hGH.2004

    • Author(s)
      Hayakawa M, Shimazaki Y, Tsushima T, Kato Y, Takano K, Chihara K, Shimatsu A, Irie
    • Journal Title

      J Clin Endocrinol Metab 89

      Pages: 1562-1571

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 成人GH分泌不全症における代謝異常2003

    • Author(s)
      肥塚直美, 他
    • Journal Title

      日本内分泌学会誌 79(Suppl)

      Pages: 114-116

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metabolic disorders in patients with adult GHdeficiency.2003

    • Author(s)
      Hizuka N, Itoh E, Fukuda I, Sata A, Tsukada J, Yasumoto K, Murakami Y, Okubo Y, Kurimoto M, Takano K
    • Journal Title

      J JapEndocr Soc 79(Suppl)

      Pages: 96-98

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pathophysiological role of 11β HSD in patients with GH deficiency and acromegaly.2003

    • Author(s)
      Hizuka N, Tsukada J
    • Journal Title

      Horumon to Rinsho 51

      Pages: 645-650

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of GH/IGF on muscle.2003

    • Author(s)
      Okubo Y, Hizuka N
    • Journal Title

      Endocrinol Diabetol 16

      Pages: 141-147

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Growth hormone secretion with age.2003

    • Author(s)
      Fukuda I, Hizuka N, Takano K
    • Journal Title

      Horumon to Rinsho 51

      Pages: 403-411

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Study of cortisol metabolism in patients with acromegaly.2003

    • Author(s)
      Tsukada J, Hizuka N, Fukuda I, Sata A, Tanaka S, Murakami Y, Ono M, Miki N, Takano K
    • Journal Title

      J JapEndocr Soc 79(Suppl)

      Pages: 45-47

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Acid-labile subunit in growth hormone excess and deficiency in adults : evaluation of its diagnostic value in comparison with insulin-like growth factor (IGF)-I and IGF-binding protein-3.2002

    • Author(s)
      Fukuda I, et al.
    • Journal Title

      Endocr J 49

      Pages: 379-386

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Acid labile subunit in growth hormone excess and deficiency in adults : evaluation of its diagnostic value in comparison with insulinlike growth factor(IGF) I and IGF binding protein.2002

    • Author(s)
      Fukuda I, Hizuka N, Itoh E, Yasumoto K, Ishikawa Y, Murakami Y, Sata A, Takano K
    • Journal Title

      Endocr J 49

      Pages: 379-386

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case with lymphocytic hypophysitis associated with diabetes insipidus.2002

    • Author(s)
      Omori K, Hizuka N, Sata A, Ishizaki R, Kawamata K, Kubo O, Hori T, Takano K
    • Journal Title

      J JapEndocr Soc 78(Suppl)

      Pages: 37-39

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case with acromegaly associated with papillary thyroid carcinoma and ovarian tumor.2002

    • Author(s)
      Itoh E, Kurimoto M, Sata A, Tsukada J, Fukuda I, Hizuka N, Takano K
    • Journal Title

      Horumon to Rinsho 50

      Pages: 323-326

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case with adult GH deficiency associated with sever coronaly insufficiency.2002

    • Author(s)
      Omori K, Ono K, Hanzawa M, Itoh E, Fukuda I, Hizuka N, Takano K
    • Journal Title

      Horumon to Rinsho 50

      Pages: 1119-1122

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Insulin-Like Growth Factors2003

    • Author(s)
      Hizuka N, et al.
    • Total Pages
      434-440
    • Publisher
      Eurekah.com.
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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