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2003 Fiscal Year Final Research Report Summary

Development for new cancer vaccine using various kinds of epitope peptides

Research Project

Project/Area Number 14571128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TSUNODA Takuya  The University of Tokyo, The Institute of Medical Science, Lecturer, 医科学研究所, 講師 (30275359)

Co-Investigator(Kenkyū-buntansha) TAKAYAMA Takuya  The University of Tokyo, The Institute of Medical Science, Research Associate, 医科学研究所, 助手 (10332579)
TAHARA Hideaki  The University of Tokyo, The Institute of Medical Science, Professor, 医科学研究所, 教授 (70322071)
Project Period (FY) 2002 – 2003
KeywordsEpitope peptide / HER2 / neu / p53 / CTL / Cancer vaccine
Research Abstract

Recently, cancer vaccine using epitope peptides was performed all over the world. Epitope peptides induced the strong cytotoxic T lymphocytes (CTL) in cancer patients, therefore clinical trials of cancer vaccine were performed. However, the outcome of clinical trial has not so excellent. One of the reasons was due to the only one target against the cancer. To promote the clinical efficacy, it is important to find the more epitope peptides. In this study, we determined the epitope peptides from HER2/neu and p53 which were significant molecules for cancer. We determined epitope peptides restricted to HLA-A*2402 which was the most common in Japanese. These findings may suggest that mixture of the epitope peptides improve the clinical efficacy of cancer vaccine.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Matsuda K, Tsunoda T., et al.: "Enhancement of Cytotoxic T Lymphocyte Responese in Patients with Gastrointestinal Malignancies following Vaccination with CEA peptide pulsed Dendritic cells"Cancer Immunology Immunotherpy. Jan20(Epub ahead of print). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saori Nakahara, Tsunoda T., et al.: "Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide."Cancer Research. 63. 4112-4118 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shono Y, Tanimura H, Iwahashi M, Tsunoda T, et al.: "Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers."Br J Cancer. 88. 530-536 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuda K, Tsunoda T., et al.: "Enhancement of Cytotoxic T Lymphocyte Responses in Patients with Gastrointestinal Malignancies following Vaccination with CEA peptide pulsed Dendritic cells"Cancer Immunology Immunotherpy.(Eub ahead of print). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saori Nakahara, Takuya Tsunoda, et al.: "Dendritic cells stimulated with a bacterial product, OK-432, efficiently induce cytotoxic T lymphocytes specific to tumor rejection peptide."Cancer Research. 63. 4112-4118 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shono Y, Tanimura H, Iwahashi M, Tsunoda T, et al.: "Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers."Br J Cancer. 88. 530-536 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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