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2004 Fiscal Year Final Research Report Summary

The relationship between gastric carcinogenesis in rodent duodenogastric-reflux model and cyclooxygenase 2 (COX-2) expression, and the chemoprevention by a specific COX-2 inhibitor

Research Project

Project/Area Number 14571183
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKanazawa University

Principal Investigator

FUJIMURA Takashi  Kanazawa University Hospital, Assistant Professor, 医学部附属病院, 講師 (50262580)

Co-Investigator(Kenkyū-buntansha) MIWA Koichi  Kanazawa University, School of Medicine, Professor, 医学系研究科, 教授 (80019968)
Project Period (FY) 2002 – 2004
KeywordsRat model for gastric carcinogenesis / Duodenogastric reflux / Cyclooxygenase 2 (COX2) / Specific COX-2 inhibitor / Chemoprevention for cancer
Research Abstract

The aims of this study are to investigate the relationship between gastric carcinogenesis by duodenogastric reflux and cyclooxygenase 2 (COX-2) expression, and to disclose the chemopreventive effect of a specific COX-2 inhibitor, meloxicam (MLX) to the development of gastric cancer. The rats surgically undergoing duodenogastric reflux were allocated to two groups, given commercial chow (Control group) and experimental chow containing MLX (0.5 mg/Kg body weight/day) (MLX group). The animals were sacrificed postoperatively at 20, 30, 40, 50, and 60 weeks. The incidence of gastritis cystica profunda (GCP), precancerous lesion, in the MLX group was significantly lower after the 30th weak than in the control group (32% vs 100%). The incidences of adenoma and adenocarcinoma in the MLX group were also significantly lower than in the control group (0% vs 52%, in adenoma, 0% vs 29%, in adenocarcinoma). The Ki-67 labeling index in the MLX group was significantly higher than in the control group through the whole experimental period. The COX-2 expression was immunohistochemically observed not only in the epithelium of GCP, adenoma and adenocarcinoma, but also in the stroma. The COX-2 mRNA expression did not differ between two groups but the level of PGE2 product in the MLX group was higher than in the control group. These results indicate that a specific COX-2 inhibitor, meloxicam, suppresses the development of GCP, adenoma and adenocarcinoma in the rodent model of gastric carcinogenesis by duodenogastric reflux, suspecting that the drug, which suppresses PGE2 production by COX-2 inhibition, prevents gastric carcinogenesis by reducing epithelial proliferation.

  • Research Products

    (10 results)

All 2004 2003 2002

All Journal Article (9 results) Book (1 results)

  • [Journal Article] 家族性大腸ポリポーシスに対するCOX-2阻害薬の効果2004

    • Author(s)
      藤村 隆
    • Journal Title

      癌治療と宿主 16

      Pages: 51-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impact of the biliary diversion procedure on carcinogenesis in Barrett's esophagus surgically induced by duodenoesophageal reflux in rats2004

    • Author(s)
      Nishijima K
    • Journal Title

      Annals of Surgery 240

      Pages: 57-67

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Anti-metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum2004

    • Author(s)
      Ninomiya I
    • Journal Title

      International Journal of Cancer 112

      Pages: 135-142

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impact of the biliary diversion procedure on carcinogenesis in Barrett's esophagus surgically induced by duodenoesophageal reflux in rats2004

    • Author(s)
      Koji Nishijima
    • Journal Title

      Annals of Surgery 240-1

      Pages: 57-67

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anti-metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum2004

    • Author(s)
      Itasu Ninomiya
    • Journal Title

      International Journal of Cancer 112-1

      Pages: 135-142

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 家族性大腸ポリポーシス患者へのCOX-2阻害薬の効果2003

    • Author(s)
      藤村 隆
    • Journal Title

      Medical Science Digest 29

      Pages: 28-31

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ラット逆流モデルにおけるBarrett上皮の発生と癌化2002

    • Author(s)
      宮下知治
    • Journal Title

      消化器科 34

      Pages: 11-17

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis2002

    • Author(s)
      Phillips RKS
    • Journal Title

      Gut 50

      Pages: 857-860

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis2002

    • Author(s)
      Phillips RKS
    • Journal Title

      Gut 50-6

      Pages: 857-860

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 消化管間葉系腫瘍(GIST)の病態・診断・治療-新しい視点2002

    • Author(s)
      藤村 隆
    • Total Pages
      149
    • Publisher
      へるす出版
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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