2003 Fiscal Year Final Research Report Summary
Effects of ghrelin on Gastrointestinal motility
| Project/Area Number |
14571193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TEZUKA Noriaki Dept.Surgery Shiga Unive. Med. Sci., 医学部, 助手 (40303771)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMIYA Mineko Dept.Anatomy Shiga Unive. Med. Sci., 医学部, 助教授 (10199359)
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| Project Period (FY) |
2002 – 2003
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| Keywords | ghrelin / gastrointestinal motility / Brain-Gut axis / Feeding behavior |
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| Research Abstract |
We found that ghrelin induces the fasted motor activity in both stomach and duodenum after injection intracerebroventricularly as well as intravenously. The study showed that fasted motor activities induced by i.c.v. or i.v. injection of ghrelin were completely blocked by immunoneutralization of NPY in the brain. Fasted motor activity induced by i.v. injection of ghrelin was not blocked by i.c.v. injection of gheliri receptor (GHS-R) antagonist, but blocked by i.v. injection of GHS-R antagonist. These findings suggest that the effects of ghrehn to induce the fasted motor activity in the GI tracts are mediated by NPY neurons in the hypothalamus. It has been reported that GHS-R is located on the cell bodies of NPY neurons in the arcuate nucleus of hypothalamus. However our recent study suggests that ghrelin released from the stomach acts on GHS-R on vagal afferent nerve terminals in the stomach wall, and information is transmitted to NTS and then to hypothalamic arcuate nucleus, where NPY neurons are activated, then finally induces the fasted motor activity in the GI tracts through dorsal motor nucleus of vagus and vagal efferent nerve fibers.
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[Publications] Fujino, K., Inui, A., Asakawa, A., Kihara, N., Fujimura, M., Fujimiya, M.: "Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats."J.Physiology. 550. 227-240
Description
「研究成果報告書概要(和文)」より
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[Publications] Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya, M., Fujino, M.A., Kasuga, M.: "Antagonism of ghrelin receptor reduces food intake and body weight gain in mice."Gut. 52. 947-952
Description
「研究成果報告書概要(和文)」より
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[Publications] Inui, A., Asakawa, A., Bowers, C.Y., Mantovani, G., Laviano, A., Meguid, M.M., Fujimiya, M.: "Ghrelin, appetite, and gastric motility-the emerging role of the stomach as an endocrine organ."FASEB J.. 18. 439-456
Description
「研究成果報告書概要(和文)」より
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[Publications] Ueno, N., Inui, A., Asakawa, A., Yuzuriha, H., Kasuga, M., Fujimiya, M: "Impaired glucose tolerance in pancreatic polypeptide-overexpressing mice."Diabetologia. 45. 1048-1049 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Fujino, K., Inui, A., Asakawa, A., Kihara, N., Fujimura, M.Fujimuya, M: "Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats."J. Physiol. 550. 227-240 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya.M., Mantyh, C., Voss, M., Eubanks, S., Harris, M., Pappas, T.N.Takahashi, T: "Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats."Am. J. Physiol. Regul. Integr. Comp. Physiol. 284. R1269-R1276 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Asakawa, A., Inui, A., Yuzuriha H., Ueno, N.,.Katsuura; G., Fujimiya, M., Fujino, M.A., Niijima, A: "Meguid, M.M. and Kasuga, M.: Characterization of the effects of pancreatic polypeptide in the regulation of energy balance."Gastroenterology. 124. 1325-1336 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya.M., Fujino, M.A., Kasuga, M: "Antagonism of ghrelin receptor reduces food intake and body weight gain in mice."Gut. 52. 947-952 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Inui, A., Asakawa, A., Bowers, C.Y., Mantovani, G., Laviano, A., Meuid, M.M., Fujimiya, M: "Ghrelin, appetite, and gastric motility -the emerging role of the stomach as an endocrine organ."FASEB J. 18. 439-456 (2004)
Description
「研究成果報告書概要(欧文)」より
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