2003 Fiscal Year Final Research Report Summary
The role of bone marrow transplantation for the ischemic hepatic injury and regeneration
| Project/Area Number |
14571215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
TSUCHIYA Takao Fukushima Medical University, Department of Surgery, Assistant professor, 医学部, 助手 (70343390)
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| Co-Investigator(Kenkyū-buntansha) |
GOTOH Mitsukazu Fukushima Medical University, Department of Surgery, Professor, 医学部, 教授 (50162160)
SATO Yoshihiro Fukushima Medical University, Department of Surgery, Assistant, 医学部, 助手 (60347218)
SAITO Takuro Fukushima Medical University, Department of Surgery, Assistant, 医学部, 助手 (20305361)
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| Project Period (FY) |
2002 – 2003
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| Keywords | hepatic regeneration / ischemic / reperfusion injury / bone marrow transplantation / green mouse / anti-GFP antibody |
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| Research Abstract |
1. After long time ischemia/reperfusion of the liver, zonal necrosis area appeared at the central vein area. After that, necrosis areas spread
2. Bone marrow cells from mice transgenic for green fluorescence protein (GFP) were transplanted to the B6 mice irradiated X-ray at a dose of 12Gy to make chimeric mice. After hepatic I/R, GFP positive cell were detected at the hepatic parenchyma and vascular endothelial cells. We suggested that hepatic endothelial cells might be replaced with these GFP positive cells at the damaged liver.
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